Studies on the Metabolism and Toxicity of N-Methyl Containing Compounds

Abstract

The influence of several factors on the oxidative metabolism of hexamethylmelamine (HMM), procarbazine, caffeine, aminopyrine (AP), N-methylformamide (NMF), and N,N-dimethylformamide was investigated in vivo. Mice were administered ¹⁴C-methyl labelled compounds and the fate of the N-methyl moiety was monitored by ¹⁴CO2 exhaled with the breath. The 1⁴CO2 exhalation profile for caffeine, but not HMM, was shown to be dependent on the dose. The influence on caffeine metabolism of inhibition or induction of cytochrome P450 dependent enzymes using SKF 525A or phenobarbitone, respectively, also depended on the dose of caffeine...

Date of Award	1983
Original language	English
Awarding Institution	Aston University