Abstract
Aspects of the metabolism and hepatotoxicity of the industrial solvent and investigational antitumour agent, N-methylformamide (NMF, OHCNHCH ) have been evaluated in mice. NMF was metabolised extensively in vivo, depleted hepatic glutathione (GSH) stores, and caused centrilobular necrosis in the liver.Pretreatment of mice with N-acetylcysteine prevented the hepatic GSH depletion and hepatotoxicity. Conversely depletion of hepatic GSH prior to NMF administration lowered the hepatotoxic dose threshold of NMF...
Date of Award | 1985 |
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Original language | English |
Awarding Institution |
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Keywords
- metabolism
- hepatotoxicity
- N-Methylformamide