The Metabolism and Hepatotoxicity of N-Methylformamide

  • Paul G. Pearson

Student thesis: Doctoral Thesis › Doctor of Philosophy

Abstract

Aspects of the metabolism and hepatotoxicity of the industrial solvent and investigational antitumour agent, N-methylformamide (NMF, OHCNHCH ) have been evaluated in mice. NMF was metabolised extensively in vivo, depleted hepatic glutathione (GSH) stores, and caused centrilobular necrosis in the liver.
Pretreatment of mice with N-acetylcysteine prevented the hepatic GSH depletion and hepatotoxicity. Conversely depletion of hepatic GSH prior to NMF administration lowered the hepatotoxic dose threshold of NMF...
Date of Award1985
Original languageEnglish
Awarding Institution
  • Aston University

Keywords

  • metabolism
  • hepatotoxicity
  • N-Methylformamide

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