Dr Colin Murdoch


Colin Murdoch

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Research interests

I am interested in how redox signaling affects cardiovascular pathophysiology.  In particular my research has concentrated on signaling in the endothelial and inflammatory cell and the implication on cardiovascular function in vivo.  I am currently investigating a number of targets in pre-eclampsia using a wide range of clinical samples, murine models and in vitro studies.  One aspect is to investigate during pre-eclampsia whether signaling is affected by the S- glutathionylation, a post-translation modification which occurs during oxidative stress.  

My previous research in Boston was to identify how angiogenesis can be regulated by S- glutathionylation.  In Kings College London I investigated the cell specific role of isoforms of the NADPH oxidase enzymes, Nox2 and Nox4 in the endothelium on left ventricular hypertrophy and hypertension. I successfully modeled a human disease in a mouse, measured cardiovascular parameters and subsequently conducted biochemical and molecular assays in order to identify novel molecular mechanisms.   

  1. Review Grant Applications

    Activity: Other activity typesTypes of Business and Community - Work on advisory panel to industry or government or non-government organisation

  2. Oxidative Medicine and Cellular Longevity (Journal)

    Activity: Publication peer-review and editorial work typesEditorial activity

  3. Frontiers in Bioscience (Journal)

    Activity: Publication peer-review and editorial work typesPublication peer-review

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Employable Graduates; Exploitable Research

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