Dr James Brown

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Dr. James Brown

  • Life & Health Sciences
  • Biosciences Research Group (BRG)
  • Aston Research Centre for Healthy Ageing

Email: brownjep@aston.ac.uk

Research output

Anti-neoplastic effect of epigallocatechin gallate on breast cancer cells through glucose metabolism

Al-shaeli, S. J., Ethaeb, A. M. & Brown, J. E., 1 Jul 2019, In : Journal of Physics: Conference Series. 1234, 012073.

Phenotypic characteristics and risk factors in a multi-ethnic cohort of young adults with type 2 diabetes

Lascar, N., Altaf, Q-A., Raymond, N. T., Brown, J. E., Pattison, H., Barnett, A., Bailey, C. J. & Bellary, S., 28 Jun 2019, In : Current Medical Research and Opinion.

Reducing readmission rates through a discharge follow-up service

Vernon, D., Brown, J. E., Griffiths, E., Nevill, A. M. & Pinkney, M., 19 Jun 2019, 6, 2, p. 114-117

Saffron (Crocus sativus L.) in ocular diseases: a narrative review of the existing evidence from clinical studies

Heitmar, R., Brown, J. E. & Kyrou, I., 18 Mar 2019, In : Nutrients. 11, 3, 649.

Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis

Kite, C., Lahart, I. M., Afzal, I., Broom, D., Randeva, H. S., Kyrou, I. & Brown, J. E., 12 Feb 2019, 8, 1, p. 51 1 p., 51.

An investigation into E-cigarette cytotoxicity in-vitro using a novel 3D differentiated co-culture model of human airways

Vasanthi Bathri Narayanan, P., Brown, J. E., Marshall, L. & Leslie, L. J., 27 Jun 2018, In : Toxicology in Vitro . 52, p. 255-264

Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA‑MB‑231 breast cancer cell line

Arif, M., Kitchen, P., Conner, M., Hill, E., Nagel, D., Bill, R., Dunmore, S., Armesilla, A., Gross, S., Carmichael, A., Conner, A. & Brown, J., May 2018, 16, 1, p. 713-720

Evidence that Differences in Fructosamine-3-Kinase Activity May be Associated with the Glycation Gap in Human Diabetes

Dunmore, S. J., Al-Derawi, A. S., Nayak, A. U., Narshi, A., Nevill, A. M., Hellwig, A., Majebi, A., Kirkham, P., Brown, J. E. & Singh, B. M., 1 Jan 2018, In : Diabetes. 67, 1

Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels

Rana, K. S., Pararasa, C., Afzal, I., Nagel, D. A., Hill, E. J., Bailey, C. J., Griffiths, H. R., Kyrou, I., Randeva, H. S., Bellary, S. & Brown, J. E., 9 Nov 2017, 16, 1

An investigation into the effects of E-cigarette aerosols using a physiologically relevant in-vitro model

Vasanthi Bathri Narayanan, P., Marshall, L. J., Brown, J. E. & Leslie, L. J., 20 Oct 2017, 280, Supplement 1, p. S266 1 p.

Hypothermia increases aquaporin 4 (AQP4) plasma membrane abundance in human primary cortical astrocytes via a calcium/transient receptor potential vanilloid 4 (TRPV4)- and calmodulin-mediated mechanism

Salman, M. M., Kitchen, P., Woodroofe, M. N., Brown, J. E., Bill, R. M., Conner, A. C. & Conner, M. T., 13 Oct 2017, In : European Journal of Neuroscience. 46, 9, p. 2542-2547 6 p.

Type 2 diabetes in adolescents and young adults

Lascar, N., Brown, J., Pattison, H., Barnett, A. H., Bailey, C. J. & Bellary, S., 5 Oct 2017, In : The Lancet Diabetes and Endocrinology. in press

Poly lactic-co-glycolic acid controlled delivery of Disulfiram to target liver cancer stem-like cells

Wang, Z., Tan, J., McConville, C., Kannappan, V., Erebi Tawari, P., Brown, J., Ding, J., Armesilla, A. L., Irache, J. M., Mei, Q-B., Tan, Y., Liu, Y., Jiang, W., Bian, X. & Wang, W., Feb 2017, 13, 2, p. 641-657 17 p.

Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells

Refaat, A., Pararasa, C., Arif, M., Brown, J. E. P., Carmichael, A., Ali, S. S., Sakurai, H. & Griffiths, H. R., 2017, In : Free Radical Research. 51, 2, p. 211-221 11 p.

The harder you run, the longer (and smoother) the road: exercise, muscle and ageing

Close, G. L. & Brown, J. E., 30 Jun 2016, In : Biogerontology. 17, 3, p. 431-433 3 p.

Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ

Pararasa, C., Ikwuobe, J., Shigdar, S., Boukouvalas, A., Nabney, I. T., Brown, J. E., Devitt, A., Bailey, C. J., Bennett, S. J. & Griffiths, H. R., Feb 2016, In : Aging Cell. 15, 1, p. 128-139 12 p.

Towards an in-vitro multi-cellular human airways model for evaluating the effects of Electronic cigarettes

Vasanthi Bathri Narayanan, P., Leslie, L. J., Brown, J. E. & Marshall, L. J., 2016, p. P20.

Amyloid β 1-42 induces hypometabolism in human stem cell-derived neuron and astrocyte networks

Tarczyluk, M. A., Nagel, D. A., Parri, H. R., Tse, E. H. Y., Brown, J. E., Coleman, M. D. & Hill, E. J., 1 Aug 2015, In : Journal of Cerebral Bood Fow and Metabolism. 35, 8, p. 1348-1357 10 p.

The interconnectedness of ageing: does the convoy principal apply?

Saffrey, J. & Brown, J. E., Apr 2015, In : Biogerontology. 16, 2, p. 131-132 2 p.

The effect of the senescence-associated secretory phenotype (SASP) on glucose homeostasis in metabolic cells

Rana, K. S., Hill, E. J., Bellary, S. & Brown, J. E., 11 Mar 2015, In : Diabetic Medicine. 32, Suppl.1, p. 93-94 2 p., P208.

Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review

Taylor, S., Lam, M., Pararasa, C., Brown, J. E. P., Carmichael, A. R. & Griffiths, H. R., 2015, In : Cancer Cell International. 15, 1, 9 p.

A novel role of plasma membrane calcium atpase 4 as a negative-regulator of VEGF-induced angiogenesis

Baggott, R. R., Alfranca, A., López-Maderuelo, M., Mohamed, T. M. A., Escolano, A., Oller, J., Ornés, B. C., Rowther, F., Oceandy, D., Kurusamy, S., Brown, J., Cartwright, E. J., Wang, W., Gómez-del Arco, P., Martínez-Martínez, S., Neyses, L., Redondo, J. M. & Armesilla, A. L., 1 Dec 2014, In : Heart. 100, Suppl.4, p. A17-A17 1 p., 050.

Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin

Baggott, R. R., Alfranca, A., López-Maderuelo, D., Mohamed, T. M. A., Escolano, A., Oller, J., Ornes, B. C., Kurusamy, S., Rowther, F. B., Brown, J. E., Oceandy, D., Cartwright, E. J., Wang, W., Gómez-del Arco, P., Martínez-Martínez, S., Neyses, L., Redondo, J. M. & Armesilla, A. L., 31 Oct 2014, In : Arteriosclerosis, Thrombosis, and Vascular biology. 34, 10, p. 2310-2320 11 p.

The interaction between metabolic disease and ageing

Rana, K. S., Griffiths, H. R., Brown, J. E., Navas, P. & Brown, J., 22 Sep 2014, In : Global Journal of Obesity, Diabetes and Metabolic Syndrome. 1, 1, 5 p., 102.

Heparanase and COX-2 expression as predictors of lymph node metastasis in large, high-grade breast tumors

Gawthorpe, S., Brown, J. E., Arif, M., Nightingale, P., Nevill, A. & Carmichael, A. R., 30 Jun 2014, In : Anticancer Research. 34, 6, p. 2797-2800 4 p.

Does metabolic reprogramming underpin age-associated changes in T cell phenotype and function?

Torrão, R. C., Bennett, S. J., Brown, J. E. & Griffiths, H. R., Jun 2014, In : Free Radical Biology and Medicine. 71, p. 26–35 10 p.

Novel expression of microRNAs in serum samples of Iraqi breast cancer women

Saad, Z., Arif, M., Yassen, N., Jasim, H., Jelawe, M. & Brown, J., 1 May 2014, In : American Journal of Biomedicine. 2, 5, p. 567-574 8 p.

Plasma irisin levels predict telomere length in healthy adults

Rana, K. S., Arif, M., Hill, E. J., Aldred, S., Nagel, D. A., Nevill, A., Randeva, H. S., Bailey, C. J., Bellary, S. & Brown, J. E., Apr 2014, In : Age. 36, 2, p. 995-1001 7 p.

Association between body composition, circulating irisin and telomere length in healthy individuals and individuals with Type 2 diabetes

Rana, K., Hill, E. J., Bailey, C. J., Bellary, S. & Brown, J. E., 31 Mar 2014, In : Diabetic Medicine. 31, s1, p. 38 1 p., P39.

Can restricting calories help you to live longer?

Brown, J. E., 13 Mar 2014, In : Post Reproductive Health. 20, 1, p. 16-18 3 p.

Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice

Morrison, F., Locke, J., Arif, M., Murray, A., Brown, J. E. & Harries, L. W., 17 Jul 2013, In : Experimental and Clinical Endocrinology and Diabetes . 121, 7, p. 413-419 7 p.

Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro

Dias, I. H. K., Chapple, I. L. C., Milward, M., Grant, M. M., Hill, E., Brown, J. & Griffiths, H. R., 24 Jun 2013, In : PLoS ONE. 8, 6, 13 p., e66407.

Intermittent fasting: a dietary intervention for prevention of diabetes and cardiovascular disease?

Brown, J. E., Mosley, M. J. & Aldred, S., Mar 2013, In : British Journal of Diabetes and Vascular Disease. 13, 2, p. 68-72 5 p.

Phytoestrogen-ind uced glucose uptake and cellular proliferation in L6 myotubesadipocyte function

Choudry, N., Robinson, J., Arif, M., Rana, K. S., Hill, E. J., Turner, S., Bailey, C. J. & Brown, J. E., Mar 2013, In : Diabetic Medicine. 30, S1, p. 39 1 p., P37.

Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells

Baggott, R. R., Mohamed, T. M. A., Oceandy, D., Holton, M., Blanc, M. C., Roux-Soro, S. C., Brown, S., Brown, J. E., Cartwright, E. J., Wang, W., Neyses, L. & Armesilla, A. L., Dec 2012, In : Carcinogenesis . 33, 12, p. 2362-2368 7 p., bgs282.

Dysregulated adipokines in the pathogenesis of type 2 diabetes and vascular disease

Brown, J. E., Sep 2012, In : British Journal of Diabetes and Vascular Disease. 12, 5, p. 249-254 6 p.

The ageing pancreas

Brown, J. E., May 2012, In : British Journal of Diabetes and Vascular Disease. 12, 3, p. 141-145 5 p.

Rapid aquaporin translocation regulates cellular water flow: the mechanism of hypotonicity-induced sub-cellular localization of the aquaporin 1 water channel

Conner, M. T., Conner, A. C., Bland, C. E., Taylor, L. H. J., Brown, J., Parri, H. R. & Bill, R. M., 30 Mar 2012, In : Journal of Biological Chemistry. 287, 14, p. 11516-11525 10 p.

The role of adipokines in beta-cell failure of type 2 diabetes

Dunmore, S. J. & Brown, J. E., 2012, In : Journal of Endocrinology. 216, 1, p. T37-T45 9 p.

Adiponectin (15-36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells: role of AMPK and MAPK kinase pathways

Ramanjaneya, M., Conner, A. C., Brown, J., Chen, J., Digby, J. E., Barber, T. M., Lehnert, H. & Randeva, H. S., May 2011, In : BBA - Molecular Cell Research. 1813, 5, p. 802-809 9 p.

Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity

Ramanjaneya, M., Chen, J., Brown, J., Tripathi, G., Hallschmid, M., Patel, S., Kern, W., Hillhouse, E. W., Lehnert, H., Tan, B. K. & Randeva, H. S., 1 Jul 2010, In : Endocrinology. 151, 7, p. 3169-3180 12 p.

Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line

Dibra, H. K., Brown, J., Hooley, P. & Nicholl, I. D., Jul 2010, In : Oncology Reports. 21, 1, p. 37-46 10 p.

Pseudoislets as primary islet replacements for research: report on a symposium at King's College London, London UK

Persaud, S. J., Arden, C., Bergsten, P., Bone, A. J., Brown, J., Dunmore, S., Harrison, M., Hauge-Evans, A., Kelly, C., King, A., Maffucci, T., Marriott, C. E., McClenaghan, N., Morgan, N. G., Reers, C., Russell, M. A., Turner, M. D., Willoughby, E., Younis, M. Y. G., Zhi, Z. L. & Jones, P. M., Jul 2010, In : Islets. 2, 4, p. 236-239 4 p.

Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin

Brown, J., Conner, A. C., Digby, J. E., Ward, K. L., Ramanjaneya, M., Randeva, H. S. & Dunmore, S. J., May 2010, In : Peptides. 31, 5, p. 944-949 6 p.

Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines

Guo, X., Xu, B., Pandey, S., Goessl, E., Brown, J., Armesilla, A. L., Darling, J. L. & Wang, W., 1 Apr 2010, In : Cancer Letters. 290, 1, p. 104-113 10 p.

Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic beta-cells

Brown, J., Onyango, D. J., Ramanjaneya, M., Conner, A. C., Patel, S. T., Dunmore, S. J. & Randeva, H. S., 1 Mar 2010, In : Journal of Molecular Endocrinology. 44, 3, p. 171-178 9 p.

Membrane trafficking of aquaporin 1 is mediated by protein kinase C via microtubules and regulated by tonicity

Conner, M. T., Conner, A. C., Brown, J. & Bill, R. M., 9 Feb 2010, In : Biochemistry. 49, 5, p. 821-823 3 p.

A novel role for the adipokine visfatin/pre-B cell colony-enhancing factor 1 in prostate carcinogenesis

Patel, S. T., Mistry, T., Brown, J., Digby, J. E., Adya, R., Desai, K. M. & Randeva, H. S., Jan 2010, In : Peptides. 31, 1, p. 51-57 7 p.

Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes

Harries, L. W., Brown, J. & Gloyn, A. L., 16 Nov 2009, In : PLoS ONE. 4, 11, 7 p., e7855.

Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B

Ramanjaneya, M., Conner, A. C., Chen, J., Kumar, P., Brown, J., Jöhren, O., Lehnert, H., Stanfield, P. R. & Randeva, H. S., 1 Aug 2009, In : Journal of Endocrinology. 202, 2, p. 249-261 13 p.

In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways

Tan, B. K., Chen, J., Adya, R., Ramanjaneya, M., Menon, V., Bailey, C. J., Brown, J., Lehnert, H. & Randeva, H. S., Aug 2009, In : Endocrinology. 150, 8, p. 3530-3539 10 p.

Leptin decreases apoptosis and alters BCL-2: bax ratio in clonal rodent pancreatic beta-cells

Brown, J. E. P. & Dunmore, S. J., Sep 2007, In : Diabetes/Metabolism Research and Reviews. 23, 6, p. 497-502 6 p.

Resistin down-regulates insulin receptor expression, and modulates cell viability in rodent pancreatic beta-cells

Brown, J. E. P., Onyango, D. J. & Dunmore, S. J., 10 Jul 2007, In : FEBS Letters. 581, 17, p. 3273-3276 4 p.

Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets

Brown, J. E. P., Thomas, S., Digby, J. E. & Dunmore, S. J., 27 Feb 2002, In : FEBS Letters. 513, 2-3, p. 189-192 4 p.

Press clippings

BBC Trust Me I'm a Doctor

James Brown


1 media contribution

BBC Trust Me I'm a Doctor

James Brown


1 media contribution

BBC Trust Me I'm a Doctor

James Brown


1 media contribution

Discussion on childhood obesity figures

James Brown


1 item of media coverage

Exercise link to ageing

James Brown


1 item of media coverage

Intermittent fasting as a preventative intervention in diabetes and heart disease

James Brown


6 items of media coverage

Old School With The Hairy Bikers

James Brown


1 media contribution

The Conversation: "Who lives longest: meat eaters or vegetarians?"

James Brown


1 item of media coverage

The Truth About Fat

James Brown


1 media contribution

The Truth About Healthy Eating

James Brown


1 media contribution

Walking is 'magic pill' to fight disease

James Brown


1 item of media coverage

Employable Graduates; Exploitable Research

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