Raj Badhan

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General

joined Aston University in June 2010 as Lecturer in Pharmacokinetics following over 3 years of extensive pharmacokinetics training with the world-renowned Centre for Applied Pharmacokinetics Research as a post-doctorate research associate, within the School of Pharmacy at the University of Manchester.

I have a broad background and interest in identifying and modulating cellular mechanisms impacting upon drug/chemical biodistribution and pharmacokinetics.  Key to this approach has been the merging of bioinformatics and pharmacokinetics in-silico approaches to provide mechanisms that may yielding predictions of human drug biodistribution during early preclinical development phases. 

As a pharmacokineticist and practicing pharmacist, I have a singular vision of developing tools and approaches which provide clear end-user/clinical benefits.  This approach has driven successes in developing preclinical research tools to predict oral drug absorption and central nervous system drug biodistribution.  

The research carried out within our group is highly diverse and we actively encourage the amalgamation of cellular and molecular biology techniques with in silico mathematical approaches to drive the mechanistic prediction and optimisation of in-vivo pharmacokinetics for drugs and novel dosage forms targetting the central nervous system.

Research interests

Pharmacokinetics plays a vital component in the drug discovery and development process, and provides critical and quantitative knowledge on how a drug enters and is processed by the body. Pharmacokinetics aims to quantify and improve prediction at all steps between drug discovery and use with mechanism-based modelling methodologies.

Our goal is to provide guidance in the development, evaluation and implementation of in vitro and in silico approaches for predicting and improving human clinical pharmacokinetics to optimise dosing and pharmacodynamic response.
Research strands actively pursued within this group include:

  • CNS targetting and durgdelivery

  • Whole Body Physiologically-Based Pharmacokinetic Modelling

  • In-vitro and in-vivo microdialysis

  • Systems biology and bioinformatics:  Drug transporter modelling

 

Opportunities are available for prospective self-funded MPhil and PhD level research students to conduct research in the area of Pharmacokinetics/Pharmacometrics within the School of Pharmacy. Please contact me for more details.

Collaborative research is welcome and encouraged, please contact me for more details.

Teaching Activity

PH1403: Mathematics.
PH2503: Stability kinetics.
PH3603 (module coordinator): Pharmacokinetics, biopharmaceutics.

I am the module coordinator and teach  3rd year MPharm Pharmaceutics module PH3CT1 (Pharmacokinetics, Biopharmaceutics) and MSc. Drug Delivery/Pharmaceutical Sciences module BI4010.  I also teach Stability Kinetics (PH2CT2) and mathematics (PH1CT1) throughout the MPharm course.

Qualifications

  • MPharm (Masters in Pharmacy) 2(i), School of Pharmacy, University of Manchester, 2001
  • PhD (Pharmacology, Molecular Biology and Pharmacokinetics), School of Pharmacy, University of Manchester, 2005  

Employment

  • 2010-date:  Lecturer in Pharmacokinetics, School of Pharmacy, Aston University
  • 2005-2009: Post-Doctorate Research Associate (Pharmacokinetics/Pharmacometrics), Centre for Applied Pharmacokinetics Research (CAPKR), School of Pharmacy, University of Manchester, United Kingdom
  • 2002-date: Locum pharmacist for national pharmacy chains 
  • 2001-2002: Pre-registration pharmacist, Superdrug Pharmacy, Wolverhampton, United Kingdom  

Membership of Professional Bodies

  • Royal Pharmaceutical Society of Great Britain
  • International Society for the Study of Xenobiotics
  • Academy of Pharmaceutical Sciences Great Britain (APSGB)
  • United Kindgom and Ireland Controlled Release Society (UKICRS)

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Life & Health Sciences

Organisational unit: School

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