A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81

Research output: Contribution to journalArticle

View graph of relations Save citation

Authors

Research units

Abstract

Tetraspanins are small transmembrane proteins, found in all higher eukaryotes, that compartmentalize cellular membranes through interactions with partner proteins. CD81 is a prototypical tetraspanin and contributes to numerous physiological and pathological processes, including acting as a critical entry
receptor for hepatitis C virus (HCV). Antibody engagement of tetraspanins can induce a variety of effects, including actin cytoskeletal rearrangements, activation of MAPK-ERK signaling and cell migration. However, the epitope specificity of most anti-tetraspanin antibodies is not known, limiting mechanistic interpretation of these studies. These novel antibodies provide well- characterised tools to investigate CD81 function, including HCV entry, and have the potential to provide insights intotetraspanin biology in general.

Documents

  • A new panel of epitope mapped monoclonal antibodies

    Rights statement: Copyright: © 2017 Grove J et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Submitted manuscript, 1 MB, PDF-document

    License: CC BY Show license

Details

Original languageEnglish
JournalWellcome Open Research
Volumein press
DOIs
StatePublished - 2017

Bibliographic note

Funding: BBSRC (BB/N007417/1); EC (LSHG-CT-2004-504601 and FP7 F3-2012-305578); MRC (MC_UU_12018/1 and G1100247); Wellcome Trust (200838); and Royal Society (107653).

DOI

Employable Graduates; Exploitable Research

Copy the text from this field...