Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging

Xianjin Cui; Salome Belo; Dirk Krüger; Yong Yan; Rafael T.M. de Rosales; Maite Jauregui-Osoro; Haitao Ye; Shi Su; Domokos Mathe; Noémi Kovács; Ildikó Horváth; Mariann Semjeni; Kavitha Sunassee; Krisztian Szigeti; Mark A. Green; Philip J. Blower

doi:10.1016/j.biomaterials.2014.04.004

Aluminium hydroxide stabilised MnFe₂O₄ and Fe₃O₄ nanoparticles as dual-modality contrasts agent for MRI and PET imaging

Xianjin Cui, Salome Belo, Dirk Krüger, Yong Yan, Rafael T.M. de Rosales, Maite Jauregui-Osoro, Haitao Ye, Shi Su, Domokos Mathe, Noémi Kovács, Ildikó Horváth, Mariann Semjeni, Kavitha Sunassee, Krisztian Szigeti, Mark A. Green, Philip J. Blower

Research output: Contribution to journal › Article › peer-review

Abstract

Magnetic nanoparticles (NPs) MnFe₂O₄ and Fe₃O₄ were stabilised by depositing an Al(OH)₃ layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [¹⁸F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for ¹⁸F-fluoride and 100% for ⁶⁴Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)₃ layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)₃ coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of ¹⁸F from NPs, but no sign of efflux of ⁶⁴Cu.

Original language	English
Pages (from-to)	5840-5846
Number of pages	7
Journal	Biomaterials
Volume	35
Issue number	22
Early online date	24 Apr 2014
DOIs	https://doi.org/10.1016/j.biomaterials.2014.04.004
Publication status	Published - 1 Jul 2014

Bibliographical note

Creative Commons Attribution 3.0 Unported (CC BY 3.0)

Open Access funded by Wellcome Trust.
Funding: Centre of Excellence in Medical Engineering funded by the Wellcome Trust; EPSRC under grant number WT088641/Z/09/Z and WT088641/Z/09/Z (in association with the MRC); King’s College London; UCL Comprehensive Cancer Imaging Centre funded by the CRUK (C1519/A10331); and National Institute for Health Research Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’ s College London. The scanning equipment funded by an equipment grant from the Wellcome Trust.

Supplementary data: http:// dx.doi.org/10.1016/j.biomaterials.2014.04.004

Keywords

magnetic nanoparticles
PET
aluminium hydroxide
dual-modal
18F

Access to Document

10.1016/j.biomaterials.2014.04.004Licence: CC BY 3.0

Aluminium hydroxide
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
Final published version, 1.64 MBLicence: CC BY 3.0

Cite this

Cui, X., Belo, S., Krüger, D., Yan, Y., de Rosales, R. T. M., Jauregui-Osoro, M., Ye, H., Su, S., Mathe, D., Kovács, N., Horváth, I., Semjeni, M., Sunassee, K., Szigeti, K., Green, M. A., & Blower, P. J. (2014). Aluminium hydroxide stabilised MnFe₂O₄ and Fe₃O₄ nanoparticles as dual-modality contrasts agent for MRI and PET imaging. Biomaterials, 35(22), 5840-5846. https://doi.org/10.1016/j.biomaterials.2014.04.004

@article{2208e8a2dc954252a0218cbb6f27db8a,

title = "Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging",

abstract = "Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [18F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for 18F-fluoride and 100% for 64Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of 18F from NPs, but no sign of efflux of 64Cu.",

keywords = "magnetic nanoparticles, PET, aluminium hydroxide, dual-modal, 18F",

author = "Xianjin Cui and Salome Belo and Dirk Kr{\"u}ger and Yong Yan and {de Rosales}, {Rafael T.M.} and Maite Jauregui-Osoro and Haitao Ye and Shi Su and Domokos Mathe and No{\'e}mi Kov{\'a}cs and Ildik{\'o} Horv{\'a}th and Mariann Semjeni and Kavitha Sunassee and Krisztian Szigeti and Green, {Mark A.} and Blower, {Philip J.}",

note = "Creative Commons Attribution 3.0 Unported (CC BY 3.0) Open Access funded by Wellcome Trust. Funding: Centre of Excellence in Medical Engineering funded by the Wellcome Trust; EPSRC under grant number WT088641/Z/09/Z and WT088641/Z/09/Z (in association with the MRC); King{\textquoteright}s College London; UCL Comprehensive Cancer Imaging Centre funded by the CRUK (C1519/A10331); and National Institute for Health Research Biomedical Research Centre at Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust and King{\textquoteright} s College London. The scanning equipment funded by an equipment grant from the Wellcome Trust. Supplementary data: http:// dx.doi.org/10.1016/j.biomaterials.2014.04.004 ",

year = "2014",

month = jul,

day = "1",

doi = "10.1016/j.biomaterials.2014.04.004",

language = "English",

volume = "35",

pages = "5840--5846",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier",

number = "22",

}

Cui, X, Belo, S, Krüger, D, Yan, Y, de Rosales, RTM, Jauregui-Osoro, M, Ye, H, Su, S, Mathe, D, Kovács, N, Horváth, I, Semjeni, M, Sunassee, K, Szigeti, K, Green, MA & Blower, PJ 2014, 'Aluminium hydroxide stabilised MnFe₂O₄ and Fe₃O₄ nanoparticles as dual-modality contrasts agent for MRI and PET imaging', Biomaterials, vol. 35, no. 22, pp. 5840-5846. https://doi.org/10.1016/j.biomaterials.2014.04.004

TY - JOUR

T1 - Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging

AU - Cui, Xianjin

AU - Belo, Salome

AU - Krüger, Dirk

AU - Yan, Yong

AU - de Rosales, Rafael T.M.

AU - Jauregui-Osoro, Maite

AU - Ye, Haitao

AU - Su, Shi

AU - Mathe, Domokos

AU - Kovács, Noémi

AU - Horváth, Ildikó

AU - Semjeni, Mariann

AU - Sunassee, Kavitha

AU - Szigeti, Krisztian

AU - Green, Mark A.

AU - Blower, Philip J.

N1 - Creative Commons Attribution 3.0 Unported (CC BY 3.0) Open Access funded by Wellcome Trust. Funding: Centre of Excellence in Medical Engineering funded by the Wellcome Trust; EPSRC under grant number WT088641/Z/09/Z and WT088641/Z/09/Z (in association with the MRC); King’s College London; UCL Comprehensive Cancer Imaging Centre funded by the CRUK (C1519/A10331); and National Institute for Health Research Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’ s College London. The scanning equipment funded by an equipment grant from the Wellcome Trust. Supplementary data: http:// dx.doi.org/10.1016/j.biomaterials.2014.04.004

PY - 2014/7/1

Y1 - 2014/7/1

N2 - Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [18F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for 18F-fluoride and 100% for 64Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of 18F from NPs, but no sign of efflux of 64Cu.

AB - Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [18F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for 18F-fluoride and 100% for 64Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of 18F from NPs, but no sign of efflux of 64Cu.

KW - magnetic nanoparticles

KW - PET

KW - aluminium hydroxide

KW - dual-modal

KW - 18F

UR - http://www.scopus.com/inward/record.url?scp=84899916123&partnerID=8YFLogxK

UR - https://www.sciencedirect.com/science/article/pii/S0142961214003676?via%3Dihub

U2 - 10.1016/j.biomaterials.2014.04.004

DO - 10.1016/j.biomaterials.2014.04.004

M3 - Article

AN - SCOPUS:84899916123

SN - 0142-9612

VL - 35

SP - 5840

EP - 5846

JO - Biomaterials

JF - Biomaterials

IS - 22

ER -