An Acoustic On-Chip Goniometer for Room Temperature Macromolecular Crystallography

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This paper describes the design, development and succesful use of an on-chip goniometer for room-temperature macromolecular crystallography via acoustically induced rotations. We present for the first time a low cost, rate-tunable, acoustic actuator for randomised in-fluid sample orientation and its utilisation for protein structure determination on a synchrotron beamline. The device enables the efficient collection of diffraction data via a rotation method from a sample within a surface confined droplet. This method facillitates efficient macromolecular structural data acquisition in fluid environments for dynamical studies.



Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalLab on a Chip
Publication statusPublished - 1 Nov 2017

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© Royal Society of Chemistry 2017 Funding: Strategic Award from the Wellcome Trust and the Biotechnology and Biological Sciences Research Council (grant 102593).


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