Calcitonin Gene-Related Peptide and Adrenomedullin Receptors

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Calcitonin gene-related peptide (CGRP) and adrenomedullin are related peptides, which are potent vasodilators. The CGRP and adrenomedullin receptors are unusual receptors, comprising a G-protein-coupled receptor (GPCR) with receptor activity-modifying proteins (RAMPs). The GPCR, the calcitonin receptor-like receptor (CLR), forms a CGRP receptor with RAMP1, whereas CLR with RAMP2 or RAMP3 forms two subtypes of adrenomedullin receptor. This article covers the pharmacology of these receptors, their distribution, and potential involvement in disease.


Publication date15 Feb 2013
Publication titleEncyclopedia of Biological Chemistry : Second Edition
Number of pages5
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
Original languageEnglish


  • Adrenomedullin, Calcitonin gene-related peptide, G-protein-coupled receptor, Receptor activity-modifying protein

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