Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I)

Natalya A. Vorotnikova, Olga A. Efremova, Alphiya R. Tsygankova, Konstantin A. Brylev, Mariya V. Edeleva, Olga G. Kurskaya, Andrew J. Sutherland, Alexandr M. Shestopalov, Yuri V. Mironov, Michael A. Shestopalov*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Halide octahedral molybdenum clusters [(Mo6X8)L6]n- possess luminescence properties that are highly promising for biological applications. These properties are rather dependent on the nature of both the inner ligands X (i.e. Cl, Br, or I) and the apical organic or inorganic ligands L. Herein, the luminescence properties and the toxicity of thiol-modified polystyrene microbeads (PS-SH) doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I) were studied and evaluated using human epidermoid larynx carcinoma (Hep2) cell cultures. According to our data, the photoluminescence quantum yield of (Mo6I8)@PS-SH is significantly higher (0.04) than that of (Mo6Cl8)@PS-SH (6Br8)@PS-SH (6X8)@PS-SH showed that all three types of doped microbeads had no significant effect on the viability and proliferation of the cells.

Original languageEnglish
Pages (from-to)922– 928
Number of pages7
JournalPolymers for Advanced Technologies
Volume27
Issue number7
Early online date11 Jan 2016
DOIs
Publication statusPublished - 13 Jun 2016

Bibliographical note

This is the peer reviewed version of the following article: Vorotnikova, N. A., Efremova, O. A., Tsygankova, A. R., Brylev, K. A., Edeleva, M. V., Kurskaya, O. G., ... Shestopalov, M. A. (2016). Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I). Polymers for advanced technologies, Early view., which has been published in final form at http://dx.doi.org/10.1002/pat.3749. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Funding: Russian Science Foundation (14-14-00192); Royal Society (IE140281); and FP7 Marie Curie Inter-European Fellowship (327440)

Keywords

  • cytotoxicity
  • molybdenum cluster complex
  • photoluminescence
  • polystyrene microbeads

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