Communicating with the dead: lipids, lipid mediators and extracellular vesicle

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Abstract

Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here we consider apoptotic cell-derived extracellular vesicles (ACdEV) and the role of contained lipids and lipid mediators in ensuring effective control of inflammation. We discuss key outstanding issues in the study of cell death and cell communication, and introduce the concept of the ‘active extracellular vesicle’ as a metabolically-active and potentially changing intercellular communicator.

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  • Devitt et al. Accepted Author Manuscript

    Rights statement: © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. Communicating with the dead: lipids, lipid mediators and extracellular vesicles Andrew Devitt, Helen R. Griffiths, Ivana MilicBiochemical Society Transactions May 2018, BST20160477; DOI: 10.1042/BST20160477

    Accepted author manuscript, 687 KB, PDF-document

Details

Original languageEnglish
Pages (from-to)631-639
JournalBiochemical Society Transactions
Volume46
Issue number3
Early online date9 May 2018
DOIs
Publication statusE-pub ahead of print - 9 May 2018

Bibliographic note

© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. Communicating with the dead: lipids, lipid mediators and extracellular vesicles Andrew Devitt, Helen R. Griffiths, Ivana MilicBiochemical Society Transactions May 2018, BST20160477; DOI: 10.1042/BST20160477 Funding: BBSRC grant (56253)

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