Copper complexes as a source of redox active MRI contrast agents

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Abstract

The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

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Original languageEnglish
Pages (from-to)903-912
Number of pages10
JournalBioMetals
Volume28
Issue number5
Early online date9 Aug 2015
DOIs
Publication statusPublished - 2015

Bibliographic note

The final publication is available at Springer via http://dx.doi.org/10.1007/s10534-015-9875-3 Funding: BBSRC (BBS/B/01553). Electronic supplementary material (doi: 10.1007/s10534-015-9875-3).

    Keywords

  • copper macrocycles, oxidation–reduction, Redox sensitive contrast agent, imaging, inflammation

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