Corticobasal degeneration and dementia

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  • R.A. Armstrong

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Corticobasal degeneration is a rare, progressive neurodegenerative disorder which significantly impairs movement. The most common initial symptom is asymmetric limb clumsiness with or without accompanying rigidity or tremor. Subsequently, the disease progresses to affect gait and there is a slow progression to influence ipsilateral arms and legs. Apraxia and dementia are the most common cortical signs. Clinical diagnosis of the disorder is difficult as the symptoms resemble those of related neurodegenerative disorders. Histopathologically, there is widespread neuronal and glial pathology including tau-immunoreactive neuronal cytoplasmic inclusions, neuropil threads, oligodendroglial inclusions, astrocytic plaques, together with abnormally enlarged ‘ballooned’ neurons. Corticobasal degeneration has affinities both with the parkinsonian syndromes including Parkinson’s disease, progressive supranuclear palsy, and multiple system atrophy and with the fronto-temporal dementias. Treatment of corticobasal degeneration involves managing and reducing the effect of symptoms.


Publication date2015
Publication titleDiet and nutrition in dementia and cognitive decline
EditorsColin R. Martin, Victor R. Preedy
Place of PublicationLondon (UK)
Number of pages9
ISBN (Print)978-0-12-407824-6
Original languageEnglish


  • tauopathy, Parkinsonian syndrome, neuronal cytoplasmic inclusions, astrocytic plaques, corticobasal degeneration

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