Dementia with Lewy bodies

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Authors

  • R.A. Armstrong

Research units

Abstract

Dementia with Lewy bodies (‘Lewy body dementia' or ‘diffuse Lewy body disease') (DLB) is the second commonest form of dementia after Alzheimer’s disease (AD). Characteristic of DLB are: (1) fluctuating cognitive ability with variations in attention and alertness, (2) recurrent visual hallucinations, and (3) motor features including akinesia, rigidity, and tremor. Various brain regions are affected in DLD including cortical and limbic regions. Histopathologically, alpha-synuclein-immunoreactive Lewy bodies (LB) are observed in the substantia nigra and in the cerebral cortex. DLB has affinities both with the parkinsonian syndromes including Parkinson’s disease (PD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and multiple system atrophy (MSA), and with AD, which can make differential diagnosis difficult. The presence of visual hallucinations may aid differential diagnosis of the parkinsononian syndromes and occipital hypometabolism may be a useful potential method of distinguishing DLB from AD. Treatment of CBD involves managing and reducing the effect of symptoms.

Details

Publication date10 Sep 2014
Publication titleDiet and nutrition in dementia and cognitive decline
EditorsColin R. Martin, Victor R. Preedy
Place of PublicationLondon (UK)
PublisherAcademic Press
Pages91-99
Number of pages9
ISBN (Electronic)978-0-12-407824-6
ISBN (Print)978-0-12-407939-7
Original languageEnglish

    Keywords

  • synucleinopathy, Parkinsonian syndrome, Lewy body, visual hallucinations, Alzheimer's disease

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