Disappearing pressure cuffs

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Abstract

Wireless, biodegradable pressure sensors provide continuous short-term monitoring of arterial pulse in rats. Blood vessel anastomosis (connecting two open ends of vessels) is an important part of complex reconstructive surgeries including coronary artery bypass grafts (CABG), critical limb ischemia, and traumatic vascular repair. Ensuring sucient blood ow at vessel anastomoses post-procedure is crucial, yet blood ow monitoring can be inconsistent. Insucient blood ow or anastomotic failure can require repeat intervention. Boutry and colleagues have developed a biodegradable, exible, wireless sensor for the continuous monitoring of blood ow that may offer a solution. In their recent publication, Boutry et al. report their exible sensor design, which uses a fringe-eld capacitive sensor to measure capacitance changes associated with changes in vessel diameter during arterial pulsation. Their design, which can be wrapped as a cuff around an artery, uses inductive coupling with an external reader coil to wirelessly monitor the blood vessel. After in vitro testing, the device was implanted around a rat femoral artery, which has a similar diameter to a pediatric facial artery, and the output pulse wave was compared with results detected using an external Doppler ultrasound system. The pulse rate output by the device was similar to the analyzed ultrasound waveform result, and the wireless monitoring capability persisted with similar results obtained one week after implantation. The device also performed favorably in an occlusion test in which blood ow through the femoral artery was transiently blocked and then restored. This new device offers short-term continuous monitoring of vessel patency that could improve outcomes after surgical procedures requiring vessel anastomosis. The authors contend that the exible sensor readings could be optimized by improving the sampling rate of the network analyzer associated with the device. The biodegradable materials used in the device avoid the need for a subsequent procedure to remove the implant. Although further evaluation is needed in additional vessels to investigate sensor behavior to pressure loads, the results of the study have translational potential.

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  • Disappearing pressure cuffs

    Rights statement: Copyright © 2019, American Association for the Advancement of Science. This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Translational Medicine in Volume 11 number 476 23 Jan 2019, DOI: 10.1126/scitranslmed.aaw5315

    Accepted author manuscript, 135 KB, PDF-document

Details

Original languageEnglish
Article numbereaaw5315
JournalScience Translational Medicine
Volume11
Issue number476
DOIs
Publication statusPublished - 23 Jan 2019

Bibliographic note

Copyright © 2019, American Association for the Advancement of Science. This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Translational Medicine in Volume 11 number 476 23 Jan 2019, DOI: 10.1126/scitranslmed.aaw5315

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