European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST Action BM1203 (EU-ROS)

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Authors

  • Javier Egea
  • Isabel Fabregat
  • Yves M. Frapart
  • Pietro Ghezzi
  • Agnes Görlach
  • Thomas Kietzmann
  • Kateryna Kubaichuk
  • Ulla G. Knaus
  • Manuela G. Lopez
  • Gloria Olaso-Gonzalez
  • Andreas Petry
  • Rainer Schulz
  • Jose Vina
  • Paul Winyard
  • Kahina Abbas
  • Ioanna Andreadou
  • Haike Antelmann
  • Fernando Antunes
  • Mutay Aslan
  • Markus M. Bachschmid
  • Rui M. Barbosa
  • Vsevolod Belousov
  • Carsten Berndt
  • David Bernlohr
  • Esther Bertrán
  • Alberto Bindoli
  • Serge P. Bottari
  • Paula M. Brito
  • Guia Carrara
  • Ana I. Casas
  • Afroditi Chatzi
  • Niki Chondrogianni
  • Marcus Conrad
  • Marcus S. Cooke
  • João G. Costa
  • Antonio Cuadrado
  • Pham My-Chan Dang
  • Barbara De Smet
  • Bilge Debelec–butuner
  • Joe Dan Dunn
  • Amanda J. Edson
  • Mariam El Assar
  • Jamel El-Benna
  • Péter Ferdinandy
  • Ana S. Fernandes
  • Kari E. Fladmark
  • Ulrich Förstermann
  • Rashid Giniatullin
  • Zoltán Giricz
  • Anikó Görbe
  • Vaclav Hampl
  • Alina Hanf
  • Jan Herget
  • Pablo Hernansanz-Agustín
  • Melanie Hillion
  • Jinjing Huang
  • Serap Ilikay
  • Pidder Jansen-Dürr
  • Vincent Jaquet
  • Jaap A. Joles
  • Balaraman Kalyanaraman
  • Danylo Kaminskyy
  • Mahsa Karbaschi
  • Marina Kleanthous
  • Lars-Oliver Klotz
  • Bato Korac
  • Kemal Sami Korkmaz
  • Rafal Koziel
  • Damir Kračun
  • Karl-Heinz Krause
  • Vladimír Křen
  • Thomas Krieg
  • João Laranjinha
  • Antigone Lazou
  • Huige Li
  • Antonio Martínez-Ruiz
  • Reiko Matsui
  • Gethin J. Mcbean
  • Stuart P. Meredith
  • Joris Messens
  • Verónica Miguel
  • Yuliya Mikhed
  • Irina Milisav
  • Lidija Milković
  • Antonio Miranda-Vizuete
  • Milos Mojović
  • María Monsalve
  • Pierre-Alexis Mouthuy
  • John Mulvey
  • Thomas Münzel
  • Vladimir Muzykantov
  • Isabel T.N. Nguyen
  • Matthias Oelze
  • Nuno G. Oliveira
  • Carlos M. Palmeira
  • Nikoletta Papaevgeniou
  • Aleksandra Pavićević
  • Brandán Pedre
  • Fabienne Peyrot
  • Marios Phylactides
  • Gratiela G. Pircalabioru
  • Henrik E. Poulsen
  • Ignacio Prieto
  • Maria Pia Rigobello
  • Natalia Robledinos-Antón
  • Leocadio Rodríguez-mañas
  • Anabela P. Rolo
  • Francis Rousset
  • Tatjana Ruskovska
  • Nuno Saraiva
  • Shlomo Sasson
  • Katrin Schröder
  • Khrystyna Semen
  • Tamara Seredenina
  • Anastasia Shakirzyanova
  • Geoffrey L. Smith
  • Thierry Soldati
  • Ana Stancic
  • Marie José Stasia
  • Holger Steinbrenner
  • Višnja Stepanić
  • Sebastian Steven
  • Kostas Tokatlidis
  • Erkan Tuncay
  • Belma Turan
  • Fulvio Ursini
  • Jan Vacek
  • Olga Vajnerova
  • Kateřina Valentová
  • Frank van Breusegem
  • Lokman Varisli
  • Elizabeth A. Veal
  • A. Suha Yalçın
  • Olha Yelisyeyeva
  • Neven Žarković
  • Martina Zatloukalová
  • Jacek Zielonka
  • Rhian M. Touyz
  • Andreas Papapetropoulos
  • Tilman Grune
  • Santiago Lamas
  • Harald H.H.W. Schmidt
  • Fabio di Lisa
  • Andreas Daiber

Research units

Abstract

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

Documents

  • European Contribution to the study of ROS

    Rights statement: © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).

    Final published version, 4 MB, PDF-document

    Licence: CC BY-NC-ND Show licence

Details

Original languageEnglish
Pages (from-to)94-162
Number of pages69
JournalRedox biology
Volume13
Early online date18 May 2017
DOIs
StatePublished - 1 Oct 2017

Bibliographic note

© 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). Funding: COST Action BM1203 (EU-ROS), supported by COST (European Cooperation in Science and Technology) which is funded by the Horizon 2020 Framework Programme of the European Union. COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks.

    Keywords

  • antioxidants, oxidative stress, reactive nitrogen species, reactive oxygen species, redox signaling, redox therapeutics

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