GABA(A) alpha-1 subunit mediated desynchronization of elevated low frequency oscillations alleviates specific dysfunction in stroke: a case report

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Abstract

The paradoxical effects of the hypnotic imidazopyridine zolpidem, widely reported in persistent vegetative state, have been replicated recently in brain-injured and cognitively impaired patients. However, the neuronal mechanisms underlying these benefits are yet to be demonstrated. We implemented contemporary neuroimaging methods to investigate sensorimotor and cognitive improvements, observed in stroke patient JP following zolpidem administration.

Details

Original languageEnglish
Article number20097125
Pages (from-to)549-555
Number of pages6
JournalClinical Neurophysiology
Volume121
Issue number4
Early online date25 Jan 2010
DOIs
Publication statusPublished - 12 Apr 2010

    Keywords

  • magnetoencephalography, GABA, MEG, theta, beta, stroke, pathological oscillations

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