International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor

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Abstract

Historically, calcitonin gene-related peptide (CGRP) receptors have been divided into two classes, CGRP(1) and CGRP(2).After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP(1) receptor was a complex between CLR and RAMP1. It is now apparent that the CGRP(2) receptor phenotype is the result of CGRP acting at receptors for amylin and adrenomedullin. Accordingly, the term "CGRP(2)" receptor should no longer be used, and the "CGRP(1)" receptor should be known as the "CGRP" receptor.

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Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalPharmacological Reviews
Volume60
Issue number2
DOIs
Publication statusPublished - 9 Jul 2008

    Keywords

  • adrenomedullin amyloid receptors, calcitonin gene-related peptide

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