Poor practices in interrogation and interviewing techniques, including those that the scientific literature suggests are counterproductive in eliciting reliable information, have led to many miscarriages of justice around the world, undermining the reputation and trust of the legal processes and organizations involved. This chapter provides a background and history of interrogation and interviewing, one that includes a description of current models and practices and highlights the fundamental differences in the two primary philosophies in Western countries. The chapter also explores the ultimate purpose of interviewing and interrogation together with the questioning strategies that science suggests are the most effective. It is argued throughout the chapter that modern, scientifically backed, interviewing approaches should be used at all times, no matter the challenge or situation, as a pathway towards both the collection of accurate information and diligent adherence to the standards of international human rights.