Abstract
We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts.
Original language | English |
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Pages (from-to) | 503-510 |
Number of pages | 8 |
Journal | Journal of Parkinson's Disease |
Volume | 8 |
Issue number | 4 |
DOIs | |
Publication status | Published - 17 Oct 2018 |
Bibliographical note
©2018 IOS Press.Keywords
- biomarker
- LRRK2 mutation
- Parkinson’s disease
- voice