Magnetoencephalography in the study of epilepsy and consciousness

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Abstract

The neural bases of altered consciousness in patients with epilepsy during seizures and at rest have raised significant interest in the last decade. This exponential growth has been supported by the parallel development of techniques and methods to investigate brain function noninvasively with unprecedented spatial and temporal resolution. In this article, we review the contribution of magnetoencephalography to deconvolve the bioelectrical changes associated with impaired consciousness during seizures. We use data collected from a patient with refractory absence seizures to discuss how spike-wave discharges are associated with perturbations in optimal connectivity within and between brain regions and discuss indirect evidence to suggest that this phenomenon might explain the cognitive deficits experienced during prolonged 3/s spike-wave discharges. © 2013 Elsevier Inc.

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Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalEpilepsy and Behavior
Volume30
DOIs
Publication statusPublished - Jan 2014

    Keywords

  • Absence seizures, Connectivity, Epilepsy, Magnetoencephalography, Phase lag index

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