MARK-AGE biomarkers of ageing

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  • Alexander Bürkle
  • María Moreno-Villanueva
  • Jürgen Bernhard
  • María Blasco
  • Gerben Zondag
  • Jan H.J. Hoeijmakers
  • Olivier Toussaint
  • Beatrix Grubeck-Loebenstein
  • Eugenio Mocchegiani
  • Sebastiano Collino
  • Efstathios S. Gonos
  • Ewa Sikora
  • Daniela Gradinaru
  • Martijn Dollé
  • Michel Salmon
  • Peter Kristensen
  • Claude Libert
  • Tilman Grune
  • Nicolle Breusing
  • Andreas Simm
  • Claudio Franceschi
  • Miriam Capri
  • Duncan Talbot
  • Paola Caiafa
  • Bertrand Friguet
  • P. Eline Slagboom
  • Antti Hervonen
  • Mikko Hurme
  • Richard Aspinall

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Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.


  • MARK-AGE biomarkers of ageing

    Rights statement: © 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (

    Final published version, 574 KB, PDF-document

    Licence: CC BY-NC-ND Show licence


Original languageEnglish
Pages (from-to)2-12
Number of pages11
JournalMechanisms of Ageing and Development
Early online date24 Mar 2015
Publication statusPublished - Nov 2015

Bibliographic note

© 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license ( European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880.


  • ageing biomarkers, human studies, MARK-AGE

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