Mechanisms of life span extension by rapamycin in the fruit fly drosophila melanogaster

Research output: Contribution to journalArticle

View graph of relations Save citation

Open

Authors

Research units

Abstract

The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. The central component of this pathway, TOR kinase, is the target of the inhibitory drug rapamycin, a highly specific and well-described drug approved for human use. We show here that feeding rapamycin to adult Drosophila produces the life span extension seen in some TOR mutants. Increase in life span by rapamycin was associated with increased resistance to both starvation and paraquat. Analysis of the underlying mechanisms revealed that rapamycin increased longevity specifically through the TORC1 branch of the TOR pathway, through alterations to both autophagy and translation. Rapamycin could increase life span of weak insulin/Igf signaling (IIS) pathway mutants and of flies with life span maximized by dietary restriction, indicating additional mechanisms.

Documents

Details

Original languageEnglish
Pages (from-to)35-46
Number of pages12
JournalCell metabolism
Volume11
Issue number1
Early online date5 Jan 2010
DOIs
Publication statusPublished - 6 Jan 2010

Bibliographic note

Open access under CC BY license.

    Keywords

  • humdisease, proteins chemistry

Download statistics

No data available

Employable Graduates; Exploitable Research

Copy the text from this field...