Neurophysiology of CSWS-associated cognitive dysfunction

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The phenomenon of continuous spikes and waves during slow-wave sleep (CSWS) is associated with a number of epileptic syndromes, which share a behavioral phenotype characterized by deterioration of cognitive, behavioral, or sensorimotor functions. Available evidence seems to suggest that spike-wave activity is a result of a complex interaction between cortical and subcortical inhibitory networks and can "per se" produce a transient loss of underlying cortical functions. Syndromes like Landau-Kleffner syndrome, CSWS, and phenomena such as negative myoclonus could share in common--at least at the neurophysiological level--some similarities. Differences in behavioral phenotypes could be explained in term of maturational and genetic differences, as well as by the functional specificity of the involved areas.


Original languageEnglish
Pages (from-to)33-36
Number of pages4
Issue numberSuppl. 7
Publication statusPublished - Aug 2009


  • Landau-Kleffner syndrome, CSWS, Magnetoencephalography, EEG-triggered fMRI, auditory sensory processing

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