Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis

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Abstract

Aim: To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes.

Materials and Methods: A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS.

Results: pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower ß-cell function (HOMA-ß; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups.

Conclusion: Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.

Details

Original languageEnglish
Pages (from-to)894-901
Number of pages8
JournalJournal of Clinical Periodontology
Volume38
Issue number10
Early online date24 Aug 2011
DOIs
Publication statusPublished - Oct 2011

    Keywords

  • adult, aged, B-lymphocytes, blood glucose, body mass index, c-reactive protein, case-control studies, HDL cholesterol, chronic periodontitis, type 2 diabetes mellitus, female, glycosylated hemoglobin A, humans, insulin resistance, male, middle aged, oxidative stress, protein carbonylation, diabetes, inflammation, periodontitis

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