Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance

Research output: Contribution to journalArticle

View graph of relations Save citation

Authors

Research units

Abstract

It is not known whether the association between increased plasma homocysteine (Hcy) associated with LDL modification and propensity for LDL uptake by macrophages in cardiovascular disease patients holds true in vascular dementia (VaD). Plasma from 83 subjects diagnosed with Alzheimer's disease (AD), VaD, mild cognitive impairment (MCI) and from controls was analysed to examine (1) whether LDL isolated from the plasma of VaD is biochemically and functionally distinct from that isolated from AD, MCI or controls; and (2) whether such biomarkers of LDL phenotype are related to plasma folate levels, Hcy levels and/or to disease severity. Folate and vitamin B6 levels were significantly lower in VaD subjects than in controls. VaD-LDL showed increased protein carbonyl content (p <0.05) and was more susceptible to scavenging by macrophages (p <0.05) than AD- or control-LDL. Patients from the VaD cohort were more prevalent in the lowest tertile for HDL:LDL and the upper tertile for LDL oxidation; the combined parameters of HDL cholesterol, LDL oxidation and scavenging by macrophages show 87% sensitivity towards VaD detection. The association between folate deficiency, LDL modification and dysfunction in VaD but not in AD may provide a novel biomarker assessment to discriminate between the diseases.

Details

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalFree Radical Research
Volume44
Issue number3
DOIs
Publication statusPublished - Mar 2010

    Keywords

  • aged, aged 80 and over, Alzheimer disease, biological markers, HDL cholesterol, LDL cholesterol, cognition disorders, vascular dementia, female, folic acid, homocysteine, humans, male, oxidation-reduction

Employable Graduates; Exploitable Research

Copy the text from this field...