TY - JOUR
T1 - Pediatric Autoimmune Epileptic Encephalopathies
AU - Wright, Sukhvir
AU - Vincent, Angela
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Pediatric autoimmune epileptic encephalopathies are predominantly characterized by the presence of autoantibodies to the surface of neuronal proteins, for example, N-methyl-d-aspartate (NMDA) receptor antibodies, but also include diseases with non-cell surface antibodies (eg, anti-Hu, glutamic-acid decarboxylase antibodies). In some cases with distinct clinical and para-clinical features, an autoimmune epileptic encephalopathy can be diagnosed without the presence of an antibody and will also respond favorably to immunotherapy. In this review, we summarize the common presentations of pediatric autoimmune epileptic encephalopathies, treatments, and outcomes, and report recent findings in the field of epilepsy, encephalopathy, and the immune system.
AB - Pediatric autoimmune epileptic encephalopathies are predominantly characterized by the presence of autoantibodies to the surface of neuronal proteins, for example, N-methyl-d-aspartate (NMDA) receptor antibodies, but also include diseases with non-cell surface antibodies (eg, anti-Hu, glutamic-acid decarboxylase antibodies). In some cases with distinct clinical and para-clinical features, an autoimmune epileptic encephalopathy can be diagnosed without the presence of an antibody and will also respond favorably to immunotherapy. In this review, we summarize the common presentations of pediatric autoimmune epileptic encephalopathies, treatments, and outcomes, and report recent findings in the field of epilepsy, encephalopathy, and the immune system.
KW - autoantibodies
KW - autoimmune epilepsy
KW - encephalopathy
KW - NMDA receptor antibody encephalitis
KW - voltage-gated potassium channel complex
UR - http://www.scopus.com/inward/record.url?scp=85012969606&partnerID=8YFLogxK
UR - http://journals.sagepub.com/doi/10.1177/0883073816685505
U2 - 10.1177/0883073816685505
DO - 10.1177/0883073816685505
M3 - Review article
C2 - 28056633
AN - SCOPUS:85012969606
SN - 0883-0738
VL - 32
SP - 418
EP - 428
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 4
ER -