Physiologically based pharmacokinetic modelling in drug delivery

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Abstract

The application of pharmacokinetic modelling within the drug development field essentially allows one to develop a quantitative description of the temporal behaviour of a compound of interest at a tissue/organ level, by identifying and defining relationships between a dose of a drug and dependent variables. In order to understand and characterise the pharmacokinetics of a drug, it is often helpful to employ pharmacokinetic modelling using empirical or mechanistic approaches. Pharmacokinetic models can be developed within mathematical and statistical commercial software such as MATLAB using traditional mathematical and computation coding, or by using the Simbiology Toolbox available within MATLAB for a graphical user interface approach to developing pharmacokinetic (PBPK) models. For formulations dosed orally, a prerequisite for clinical activity is the entry of the drug into the systemic circulation.

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Publication date29 Jun 2015
Publication titleComputational pharmaceutics : application of molecular modeling in drug delivery
EditorsDefang Ouyang, Sean C. Smith
PublisherWiley
Pages263-291
Number of pages29
ISBN (Print)978-1-118573-98-3, 978-1-118573-99-0
Original languageEnglish

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