Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins

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Abstract

Receptor activity-modifying proteins (RAMPs) are single pass membrane proteins initially identified by their ability to determine the pharmacology of the calcitonin receptor-like receptor (CLR), a family B G protein-coupled receptor (GPCR). It is now known that RAMPs can interact with a much wider range of GPCRs. This review considers recent developments on the structure of the complexes formed between the extracellular domains (ECDs) of CLR and RAMP1 or RAMP2 as these provide insights as to how the RAMPs direct ligand binding. The range of RAMP interactions is also considered; RAMPs can interact with numerous family B GPCRs as well as examples of family A and family C GPCRs. They influence receptor expression at the cell surface, trafficking, ligand binding and G protein coupling. The GPCR-RAMP interface offers opportunities for drug targeting, illustrated by examples of drugs developed for migraine.

Details

Original languageEnglish
Pages (from-to)568-573
Number of pages6
JournalBiochemical Society Transactions
Volume44
Issue number2
Early online date11 Apr 2016
DOIs
Publication statusPublished - 15 Apr 2016

Bibliographic note

This is not the final peer-reviewed Version of Record; Hay, D. L., Walker, C. S., Gingell, J. J., Ladds, G., Reynolds, C. A., & Poyner, D. R. (2016). Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins. Biochemical Society Transactions, 44(2), 568-673. http://dx.doi.org/10.1042/BST20150237

    Keywords

  • adrenomedullin, amylin, calcitonin gene-related peptide (CGRP), calcitonin receptor, calcitonin receptor-like receptor, family B G protein-coupled receptor, receptor activity-modifying protein (RAMP)

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