TY - JOUR
T1 - Reduction in blood glutathione levels occurs similarly in patients with primary-open angle or normal tension glaucoma
AU - Gherghel, Doina
AU - Mroczkowska, Stephanie
AU - Qin, Lu
PY - 2013/5/1
Y1 - 2013/5/1
N2 - PURPOSE. To investigate in parallel the systemic glutathione levels of patients suffering from primary open angle glaucoma (POAG) or normal tension glaucoma (NTG) with comparable functional loss. METHODS. Thirty-four POAG patients, 30 NTG patients, and 53 controls were subjected to blood analysis to detect the level of circulating glutathione in its reduced (GSH) and oxidized (GSSG) forms. Systemic blood pressure (BP) and ocular perfusion pressure (OPP) parameters were also determined. RESULTS. Independent of age, POAG and NTG patients demonstrated significantly lower GSH and t-GSH levels than age-matched controls (P < 0.001). Additionally, a lower redox index was found, but in POAG patients only, in comparison to both NTG and control groups (P = 0.020). GSSG levels were, however, similar between all study groups (P > 0.05). CONCLUSIONS. This study demonstrates, for the first time, that both POAG and NTG patients exhibit lower GSH and t-GSH levels than age-matched controls, indicating a similar general compromise of the antioxidant defense systems may exist in both conditions.
AB - PURPOSE. To investigate in parallel the systemic glutathione levels of patients suffering from primary open angle glaucoma (POAG) or normal tension glaucoma (NTG) with comparable functional loss. METHODS. Thirty-four POAG patients, 30 NTG patients, and 53 controls were subjected to blood analysis to detect the level of circulating glutathione in its reduced (GSH) and oxidized (GSSG) forms. Systemic blood pressure (BP) and ocular perfusion pressure (OPP) parameters were also determined. RESULTS. Independent of age, POAG and NTG patients demonstrated significantly lower GSH and t-GSH levels than age-matched controls (P < 0.001). Additionally, a lower redox index was found, but in POAG patients only, in comparison to both NTG and control groups (P = 0.020). GSSG levels were, however, similar between all study groups (P > 0.05). CONCLUSIONS. This study demonstrates, for the first time, that both POAG and NTG patients exhibit lower GSH and t-GSH levels than age-matched controls, indicating a similar general compromise of the antioxidant defense systems may exist in both conditions.
KW - glutathione
KW - normal tension glaucoma
KW - open angle glaucoma
UR - http://www.scopus.com/inward/record.url?scp=84877666417&partnerID=8YFLogxK
UR - http://iovs.arvojournals.org/article.aspx?articleid=2189298
U2 - 10.1167/iovs.12-11256
DO - 10.1167/iovs.12-11256
M3 - Article
C2 - 23599328
AN - SCOPUS:84877666417
SN - 1552-5783
VL - 54
SP - 3333
EP - 3339
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
ER -