Reproducibility and repeatability of the OcuSense TearLab™ osmometer

Research output: Contribution to journalArticle

View graph of relations Save citation

Open

Authors

Research units

Abstract

BACKGROUND: Some studies report that increased tear osmolarity is a reliable indicator of dry eye syndrome (DES). The OcuSense TearLab™ osmometer requires less than a 100-nl sample of tears and provides an instant quantitative result. Our aim was to clinically evaluate this instrument in terms of its reproducibility and repeatability. METHODS: Twenty-nine participants who ranged in age from 19 to 49 years (mean?±?SD: 23.3?±?5.5 years) were recruited. Osmolarity readings were collected by two operators, in two sessions separated by 1 or 2 weeks in order to assess test reproducibility and repeatability. RESULTS: The coefficient of reproducibility was 39 mOsms/l; the coefficient of repeatability was 33 mOsms/l. CONCLUSIONS: Our mean coefficient of variation over four readings for 29 subjects is 2.9%, which compares well with that reported by the manufacturer. Our results inform practitioners about the level of change over time that can be considered clinically relevant for healthy subjects. This value is 33mOsms/l; any change smaller than this could be attributed to measurement noise.

Documents

Details

Original languageEnglish
Pages (from-to)1201-1205
Number of pages5
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume250
Issue8
Early online date21 Feb 2012
DOIs
StatePublished - Aug 2012

Bibliographic note

The original publication is available at www.springerlink.com

    Keywords

  • dry eye, osmolarity, osmometer, TearLab, tears

DOI

Download statistics

No data available

Employable Graduates; Exploitable Research

Copy the text from this field...