Spatial distribution of diffuse, primitive, and classic amyloid-beta deposits and blood vessels in the upper laminae of the frontal cortex in Alzheimer disease

Richard A. Armstrong, Nigel J. Cairns, Peter L. Lantos

Research output: Contribution to journalArticlepeer-review

Abstract

The spatial distribution of the diffuse, primitive, and classic amyloid-beta deposits was studied in the upper laminae of the superior frontal gyrus in cases of sporadic Alzheimer disease (AD). Amyloid-beta-stained tissue was counterstained with collagen IV to determine whether the spatial distribution of the amyloid-beta deposits along the cortex was related to blood vessels. In all patients, amyloid-beta deposits and blood vessels were aggregated into distinct clusters and in many patients, the clusters were distributed with a regular periodicity along the cortex. The clusters of diffuse and primitive deposits did not coincide with the clusters of blood vessels in most patients. However, the clusters of classic amyloid-beta deposits coincided with those of the large diameter (>10 microm) blood vessels in all patients and with clusters of small-diameter (< 10 microm) blood vessels in four patients. The data suggest that, of the amyloid-beta subtypes, the clusters of classic amyloid-beta deposits appear to be the most closely related to blood vessels and especially to the larger-diameter, vertically penetrating arterioles in the upper cortical laminae.
Original languageEnglish
Pages (from-to)378-383
Number of pages6
JournalAlzheimer Disease and Associated Disorders
Volume12
Issue number4
Publication statusPublished - Dec 1998

Keywords

  • spatial distribution
  • amyloid-beta deposit
  • upper laminae
  • superior frontal gyrus
  • sporadic Alzheimer disease
  • Amyloid-beta-stained tissue
  • cortex
  • blood vessels
  • clustering

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