Sulphonated biomaterials as glycosaminoglycan mimics in wound healing

Brian J. Tighe; Aisling M. Mann

Sulphonated biomaterials as glycosaminoglycan mimics in wound healing

Brian J. Tighe, Aisling M. Mann^*

^*Corresponding author for this work

Chemical Engineering & Applied Chemistry

Research output: Chapter in Book/Published conference output › Chapter

Abstract

This chapter considers the available evidence and underlying physicochemical principles that support the proposition that a biomimetic wound dressing based on glycosaminoglycan models offers a potential means of influencing wound bioactivity. Available evidence showing advantages in wound healing for experimental proteoglycanbased dressing materials is described, together with an overview of the bioactive role of sulphated macromolecules. This leads to an assessment of the analogies between the sulphonate group and the sulphate group and an explanation of their unique water binding behaviour. The available information suggests the desirability of an integrated physicochemical, biochemical and biological approach to the design and synthesis of new wound healing biomaterials.

Original language	English
Title of host publication	Advanced wound repair therapies
Editors	David Farrar
Place of Publication	Cambridge (UK)
Publisher	Woodhead
Pages	321-357
Number of pages	37
ISBN (Print)	978-1-84569-700-6
Publication status	Published - 21 Jun 2011

Keywords

biomimesis
sulphate
sulphonate
hydrogel
proteoglycan
interfacial tension.

Cite this

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title = "Sulphonated biomaterials as glycosaminoglycan mimics in wound healing",

abstract = "This chapter considers the available evidence and underlying physicochemical principles that support the proposition that a biomimetic wound dressing based on glycosaminoglycan models offers a potential means of influencing wound bioactivity. Available evidence showing advantages in wound healing for experimental proteoglycanbased dressing materials is described, together with an overview of the bioactive role of sulphated macromolecules. This leads to an assessment of the analogies between the sulphonate group and the sulphate group and an explanation of their unique water binding behaviour. The available information suggests the desirability of an integrated physicochemical, biochemical and biological approach to the design and synthesis of new wound healing biomaterials.",

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N2 - This chapter considers the available evidence and underlying physicochemical principles that support the proposition that a biomimetic wound dressing based on glycosaminoglycan models offers a potential means of influencing wound bioactivity. Available evidence showing advantages in wound healing for experimental proteoglycanbased dressing materials is described, together with an overview of the bioactive role of sulphated macromolecules. This leads to an assessment of the analogies between the sulphonate group and the sulphate group and an explanation of their unique water binding behaviour. The available information suggests the desirability of an integrated physicochemical, biochemical and biological approach to the design and synthesis of new wound healing biomaterials.

AB - This chapter considers the available evidence and underlying physicochemical principles that support the proposition that a biomimetic wound dressing based on glycosaminoglycan models offers a potential means of influencing wound bioactivity. Available evidence showing advantages in wound healing for experimental proteoglycanbased dressing materials is described, together with an overview of the bioactive role of sulphated macromolecules. This leads to an assessment of the analogies between the sulphonate group and the sulphate group and an explanation of their unique water binding behaviour. The available information suggests the desirability of an integrated physicochemical, biochemical and biological approach to the design and synthesis of new wound healing biomaterials.

KW - biomimesis

KW - sulphate

KW - sulphonate

KW - hydrogel

KW - proteoglycan

KW - interfacial tension.

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M3 - Chapter

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BT - Advanced wound repair therapies

A2 - Farrar, David

PB - Woodhead

CY - Cambridge (UK)

ER -

Sulphonated biomaterials as glycosaminoglycan mimics in wound healing

Abstract

Keywords

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Wound healing studies and interfacial phenomena: use and relevance of the corneal model

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