Synthesis of potent water-soluble tissue transglutaminase inhibitors

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Abstract

Dipeptide-based sulfonium peptidylmethylketones derived from 6-diazo-5-oxo-L-norleucine (DON) have been investigated as potential water-soluble inhibitors of extracellular transglutaminase. The lead compounds were prepared in four steps and exhibited potent activity against tissue transglutaminase.

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Original languageEnglish
Pages (from-to)5559-5562
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number20
DOIs
Publication statusPublished - 15 Oct 2008

    Keywords

  • transglutaminase, inhibitors, dipeptide

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