Systemic circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk

Swathi Seshadri; Stephanie Mroczkowska; Lu Qin; Sunni Patel; Aniko Ekárt; Doina Gherghel

doi:10.1111/aos.12594

Systemic circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk

Swathi Seshadri, Stephanie Mroczkowska, Lu Qin, Sunni Patel, Aniko Ekárt, Doina Gherghel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To investigate the relationship between retinal microvascular reactivity, circulatory markers for CVD risk and systemic antioxidative defence capacity in healthy middle-aged individuals with low to moderate risk of CVD.

Methods: Retinal vascular reactivity to flickering light was assessed in 102 healthy participants (46-60 years) by means of dynamic retinal vessel analysis (DVA). Other vascular assessments included carotid intima-media thickness (C-IMT) and blood pressure (BP) measurements. Total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and blood glutathione levels in its reduced (GSH) and oxidized (GSSG) forms were also determined for each participant, along with Framingham risk scores (FRS).

Results: Retinal arterial baseline diameter fluctuation (BDF) was independently, significantly and negatively influenced by LDL-C levels (β = -0.53, p = 0.027). Moreover, the arterial dilation slope (Slope_AD) was independently, significantly and positively associated with redox index (GSH: GSSG ratio, β = 0.28, p = 0.016), while the arterial constriction slope (Slope_AC) was significantly and negatively influenced by blood GSH levels (β = -0.20, p = 0.042), and positively associated with FRS (β = 0.25, p = 0.009). Venous BDF and dilation amplitude (DA) were also negatively influenced by plasma LDL-C levels (β = -0.83, p = 0.013; and β = -0.22, p = 0.028, respectively).

Conclusions: In otherwise healthy individuals with low to moderate cardiovascular risk, retinal microvascular dilation and constriction responses to stress levels are influenced by systemic antioxidant capacity, and circulating markers for cardiovascular risk.

Original language	English
Pages (from-to)	e266-e274
Number of pages	9
Journal	Acta Ophthalmologica
Volume	93
Issue number	4
Early online date	9 Dec 2014
DOIs	https://doi.org/10.1111/aos.12594
Publication status	Published - Jun 2015

Bibliographical note

This is the peer reviewed version of the following article: Seshadri, S., Mroczkowska, S., Qin, L., Patel, S., Ekárt, A., & Gherghel, D. (2015). Systemic circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk. Acta ophthalmologica, 93(4), e266-e274, which has been published in final form at http://dx.doi.org/10.1111/aos.12594. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Keywords

cardiovascular risk
dynamic retinal vessel analysis
oxidative stress
retina
vascular function

Access to Document

10.1111/aos.12594

Circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk
This is the peer reviewed version of the following article: Seshadri, S., Mroczkowska, S., Qin, L., Patel, S., Ekárt, A., & Gherghel, D. (2015). Systemic circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk. Acta ophthalmologica, 93(4), e266-e274, which has been published in final form at http://dx.doi.org/10.1111/aos.12594. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 144 KB

http://onlinelibrary.wiley.com/doi/10.1111/aos.12594/abstract

Cite this

@article{90b1c90c0faf41108372401ff85af7f8,

title = "Systemic circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk",

abstract = "Purpose: To investigate the relationship between retinal microvascular reactivity, circulatory markers for CVD risk and systemic antioxidative defence capacity in healthy middle-aged individuals with low to moderate risk of CVD. Methods: Retinal vascular reactivity to flickering light was assessed in 102 healthy participants (46-60 years) by means of dynamic retinal vessel analysis (DVA). Other vascular assessments included carotid intima-media thickness (C-IMT) and blood pressure (BP) measurements. Total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and blood glutathione levels in its reduced (GSH) and oxidized (GSSG) forms were also determined for each participant, along with Framingham risk scores (FRS). Results: Retinal arterial baseline diameter fluctuation (BDF) was independently, significantly and negatively influenced by LDL-C levels (β = -0.53, p = 0.027). Moreover, the arterial dilation slope (SlopeAD) was independently, significantly and positively associated with redox index (GSH: GSSG ratio, β = 0.28, p = 0.016), while the arterial constriction slope (SlopeAC) was significantly and negatively influenced by blood GSH levels (β = -0.20, p = 0.042), and positively associated with FRS (β = 0.25, p = 0.009). Venous BDF and dilation amplitude (DA) were also negatively influenced by plasma LDL-C levels (β = -0.83, p = 0.013; and β = -0.22, p = 0.028, respectively). Conclusions: In otherwise healthy individuals with low to moderate cardiovascular risk, retinal microvascular dilation and constriction responses to stress levels are influenced by systemic antioxidant capacity, and circulating markers for cardiovascular risk.",

keywords = "cardiovascular risk, dynamic retinal vessel analysis, oxidative stress, retina, vascular function",

author = "Swathi Seshadri and Stephanie Mroczkowska and Lu Qin and Sunni Patel and Aniko Ek{\'a}rt and Doina Gherghel",

note = "This is the peer reviewed version of the following article: Seshadri, S., Mroczkowska, S., Qin, L., Patel, S., Ek{\'a}rt, A., & Gherghel, D. (2015). Systemic circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk. Acta ophthalmologica, 93(4), e266-e274, which has been published in final form at http://dx.doi.org/10.1111/aos.12594. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.",

year = "2015",

month = jun,

doi = "10.1111/aos.12594",

language = "English",

volume = "93",

pages = "e266--e274",

journal = "Acta Ophthalmologica",

issn = "1755-375X",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Systemic circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk

AU - Seshadri, Swathi

AU - Mroczkowska, Stephanie

AU - Qin, Lu

AU - Patel, Sunni

AU - Ekárt, Aniko

AU - Gherghel, Doina

N1 - This is the peer reviewed version of the following article: Seshadri, S., Mroczkowska, S., Qin, L., Patel, S., Ekárt, A., & Gherghel, D. (2015). Systemic circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk. Acta ophthalmologica, 93(4), e266-e274, which has been published in final form at http://dx.doi.org/10.1111/aos.12594. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

PY - 2015/6

Y1 - 2015/6

N2 - Purpose: To investigate the relationship between retinal microvascular reactivity, circulatory markers for CVD risk and systemic antioxidative defence capacity in healthy middle-aged individuals with low to moderate risk of CVD. Methods: Retinal vascular reactivity to flickering light was assessed in 102 healthy participants (46-60 years) by means of dynamic retinal vessel analysis (DVA). Other vascular assessments included carotid intima-media thickness (C-IMT) and blood pressure (BP) measurements. Total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and blood glutathione levels in its reduced (GSH) and oxidized (GSSG) forms were also determined for each participant, along with Framingham risk scores (FRS). Results: Retinal arterial baseline diameter fluctuation (BDF) was independently, significantly and negatively influenced by LDL-C levels (β = -0.53, p = 0.027). Moreover, the arterial dilation slope (SlopeAD) was independently, significantly and positively associated with redox index (GSH: GSSG ratio, β = 0.28, p = 0.016), while the arterial constriction slope (SlopeAC) was significantly and negatively influenced by blood GSH levels (β = -0.20, p = 0.042), and positively associated with FRS (β = 0.25, p = 0.009). Venous BDF and dilation amplitude (DA) were also negatively influenced by plasma LDL-C levels (β = -0.83, p = 0.013; and β = -0.22, p = 0.028, respectively). Conclusions: In otherwise healthy individuals with low to moderate cardiovascular risk, retinal microvascular dilation and constriction responses to stress levels are influenced by systemic antioxidant capacity, and circulating markers for cardiovascular risk.

AB - Purpose: To investigate the relationship between retinal microvascular reactivity, circulatory markers for CVD risk and systemic antioxidative defence capacity in healthy middle-aged individuals with low to moderate risk of CVD. Methods: Retinal vascular reactivity to flickering light was assessed in 102 healthy participants (46-60 years) by means of dynamic retinal vessel analysis (DVA). Other vascular assessments included carotid intima-media thickness (C-IMT) and blood pressure (BP) measurements. Total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and blood glutathione levels in its reduced (GSH) and oxidized (GSSG) forms were also determined for each participant, along with Framingham risk scores (FRS). Results: Retinal arterial baseline diameter fluctuation (BDF) was independently, significantly and negatively influenced by LDL-C levels (β = -0.53, p = 0.027). Moreover, the arterial dilation slope (SlopeAD) was independently, significantly and positively associated with redox index (GSH: GSSG ratio, β = 0.28, p = 0.016), while the arterial constriction slope (SlopeAC) was significantly and negatively influenced by blood GSH levels (β = -0.20, p = 0.042), and positively associated with FRS (β = 0.25, p = 0.009). Venous BDF and dilation amplitude (DA) were also negatively influenced by plasma LDL-C levels (β = -0.83, p = 0.013; and β = -0.22, p = 0.028, respectively). Conclusions: In otherwise healthy individuals with low to moderate cardiovascular risk, retinal microvascular dilation and constriction responses to stress levels are influenced by systemic antioxidant capacity, and circulating markers for cardiovascular risk.

KW - cardiovascular risk

KW - dynamic retinal vessel analysis

KW - oxidative stress

KW - retina

KW - vascular function

UR - http://www.scopus.com/inward/record.url?scp=84929516563&partnerID=8YFLogxK

U2 - 10.1111/aos.12594

DO - 10.1111/aos.12594

M3 - Article

AN - SCOPUS:84929516563

SN - 1755-375X

VL - 93

SP - e266-e274

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

IS - 4

ER -

Systemic circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this