The activation of the CGRP receptor

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Abstract

The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

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Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalBiochemical Society Transactions
Volume41
Issue number1
DOIs
Publication statusPublished - Feb 2013

Bibliographic note

Funding: Wellcome Trust [091496]; Medical Research Council [G1001812]

    Keywords

  • alanine scan, family A GPCRs, family B GPCRs, mutagenesis, secretin-like GPCR, structure–activity relationship

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