The interface between Alzheimer's disease, normal aging, and related disorders

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Authors

  • Richard A. Armstrong

Research units

Abstract

Since the earliest descriptions of Alzheimer's disease (AD), the presence of senile plaques (SP) and neurofibrillary tangles (NFT) have been regarded as the typical pathological hallmarks of the disease. Studies over the last twenty years, however, have reported a considerable degree of heterogeneity within the AD phenotype and as a consequence, an overlap between the pathological features of AD not only with normal aging, but also with disorders related to AD. This review discusses: 1) the degree of heterogeneity within AD, 2) the concept of an 'interface' between disorders, 3) the nature and degree of the interface between AD and normal aging, vascular dementia (VD), the tauopathies, synucleinopathies, and prion disease, and 4) whether the original status of AD should be retained or whether AD, normal aging, and the related disorders should be regarded as representing a 'continuum' of neuropathological change.

Details

Original languageEnglish
Pages (from-to)122-132
Number of pages11
JournalCurrent Aging Science
Volume1
Issue number2
DOIs
Publication statusPublished - Jul 2008

    Keywords

  • Alzheimer's disease, senile plaques, neurofibrillary tangles, pathological features, aging, vascular dementia, tauopathies, synucleinopathies, prion disease

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