The role of ERK5 in endothelial cell function

Gopika N. Nithianandarajah-Jones; Bettina Wilm; Christopher E.P. Goldring; Jürgen Müller; Michael J. Cross

doi:10.1042/BST20140276

The role of ERK5 in endothelial cell function

Gopika N. Nithianandarajah-Jones, Bettina Wilm, Christopher E.P. Goldring, Jürgen Müller, Michael J. Cross^*

^*Corresponding author for this work

Aston Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Extracellular-signal-regulated kinase 5 (ERK5), also termed big MAPK1 (BMK1), is the most recently discovered member of the mitogen-activated protein kinase (MAPK) family. It is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that, in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.

Original language	English
Pages (from-to)	1584-1589
Number of pages	6
Journal	Biochemical Society Transactions
Volume	42
Issue number	6
DOIs	https://doi.org/10.1042/BST20140276
Publication status	Published - 1 Dec 2014

Bibliographical note

© The Authors Journal compilation © 2014 Biochemical Society.
This verion is not the final peer-reviewed Version of Record.

Keywords

angiogenesis big MAPK1 (BMK1)
endothelial cell
extracellular-signal-regulated kinase 5 (ERK5)
mitogen-activated protein kinase (MAPK)
signal transduction

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10.1042/BST20140276

ERK5 in endothelial cell function
© The Authors Journal compilation © 2014 Biochemical Society. This verion is not the final peer-reviewed Version of Record.
Accepted author manuscript, 252 KB

http://www.biochemsoctrans.org/content/42/6/1584.full-text.pdf

Cite this

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abstract = "Extracellular-signal-regulated kinase 5 (ERK5), also termed big MAPK1 (BMK1), is the most recently discovered member of the mitogen-activated protein kinase (MAPK) family. It is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that, in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.",

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The role of ERK5 in endothelial cell function

Abstract

Bibliographical note

Keywords

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