The value of magnetoencephalography to guide electrode implantation in epilepsy

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Abstract

Purpose: To investigate if magnetoencephalography (MEG) can identify implantation sites for intracranial recordings (IR).
Method: Two groups of 12 patients assessed for surgery with IR with and without MEG were compared (MEG and control groups). In the control group, non-invasive presurgical assessment without MEG suggested clear hypotheses for implantation. In the MEG group, non-invasive assessment was inconclusive, and MEG was used to identify implantation sites. Both groups were matched for implantation type. The success of implantation was defined by findings in IR: a) Focal seizure onset; b)Unilateral focal abnormal responses to single pulse electrical stimulation(SPES); and c) Concordance between a) and b).
Results: In all MEG patients, at least one virtual MEG electrode generated suitable hypotheses for the location of implantations. The proportion of patients showing focal seizure onset restricted to one hemisphere was similar in control and MEG groups (6/12 vs. 11/12, Fisher’s exact test,p = 0.0686). The proportion of patients showing unilateral responses to SPES was lower in the control than in the MEG group (7/12 vs. 12/12,p = 0.0373).
Conclusion: The MEG group showed similar or higher incidence of successful implantations than controls.

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Original languageEnglish
Article numberP902
Pages (from-to)283-284
Number of pages2
JournalEpilepsia
Volume54
Issue numberS3
DOIs
StatePublished - Jun 2013
Event30th international epilepsy congress - Montreal, Canada
Duration: 23 Jun 201327 Jun 2013

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Special Issue: 30th International Epilepsy Congress, Montreal, Canada, 23 – 27 June 2013

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