Thiosemicarbazones active against Clostridium difficile

Cait Costello; Tarja Karpanen; Peter A. Lambert; Preena Mistry; Katy J. Parker; Daniel L. Rathbone; Jiangmeng Ren; Laura Wheeldon; Tony Worthington

doi:10.1016/j.bmcl.2008.01.041

Thiosemicarbazones active against Clostridium difficile

Cait Costello, Tarja Karpanen, Peter A. Lambert, Preena Mistry, Katy J. Parker, Daniel L. Rathbone, Jiangmeng Ren, Laura Wheeldon, Tony Worthington

Research output: Contribution to journal › Article › peer-review

Abstract

A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.

Original language	English
Pages (from-to)	1708-1711
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2008.01.041
Publication status	Published - 1 Mar 2008

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic and Medicinal Chemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Costello, Cait; Karpanen, Tarja; Lambert, Peter A.; Mistry, Preena; Parker, Katy J.; Rathbone, Daniel L.; Ren, Jiangmeng; Wheeldon, Laura and Worthington, Tony (2008). Thiosemicarbazones active against Clostridium difficile. Bioorganic and Medicinal Chemistry Letters, 18 (5), pp. 1708-1711. DOI 10.1016/j.bmcl.2008.01.041

Keywords

thiosemicarbazone
Clostridium difficile
antimicrobial
nitrofuran

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10.1016/j.bmcl.2008.01.041

BMCL_2008_17081711.pdf
NOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic and Medicinal Chemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Costello, Cait; Karpanen, Tarja; Lambert, Peter A.; Mistry, Preena; Parker, Katy J.; Rathbone, Daniel L.; Ren, Jiangmeng; Wheeldon, Laura and Worthington, Tony (2008). Thiosemicarbazones active against Clostridium difficile. Bioorganic and Medicinal Chemistry Letters, 18 (5), pp. 1708-1711. DOI 10.1016/j.bmcl.2008.01.041

http://dx.doi.org/10.1016/j.bmcl.2008.01.041

Cite this

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title = "Thiosemicarbazones active against Clostridium difficile",

abstract = "A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.",

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AU - Karpanen, Tarja

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AU - Rathbone, Daniel L.

AU - Ren, Jiangmeng

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AU - Worthington, Tony

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Thiosemicarbazones active against Clostridium difficile

Abstract

Bibliographical note

Keywords

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