Trigger release liposome systems: local and remote controlled delivery?

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Abstract

Target-specific delivery has become an integral area of research in order to increase bioavailability and reduce the toxic effects of drugs. As a drug-delivery option, trigger-release liposomes offer sophisticated targeting and greater control-release capabilities. These are broadly divided into two categories; those that utilise the local environment of the target site where there may be an upregulation in certain enzymes or a change in pH and those liposomes that are triggered by an external physical stimulus such as heat, ultrasound or light. These release mechanisms offer a greater degree of control over when and where the drug is released; furthermore, targeting of diseased tissue is enhanced by incorporation of target-specific components such as antibodies. This review aims to show the development of such trigger release liposome systems and the current research in this field.

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Original languageEnglish
Pages (from-to)262-276
Number of pages15
JournalJournal of Microencapsulation
Volume29
Issue number3
DOIs
Publication statusPublished - May 2012

    Keywords

  • vesicles, liposomes, trigger release , photosensitive, ultrasound, enzyme-triggered release, thermosensitive

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