When change is the only constant:  The promise of longitudinal neuroimaging in understanding social anxiety disorder

Simone P.W. Haller; Kathryn L. Mills; Charlotte Hartwright; Anthony S. David; Kathrin Cohen Kadosh

doi:10.1016/j.dcn.2018.05.005

When change is the only constant: The promise of longitudinal neuroimaging in understanding social anxiety disorder

Simone P.W. Haller, Kathryn L. Mills, Charlotte Hartwright, Anthony S. David, Kathrin Cohen Kadosh

Research output: Contribution to journal › Article › peer-review

Abstract

Longitudinal studies offer a unique window into developmental change. Yet, most of what we know about the pathophysiology of psychiatric disorders is based on cross-sectional work. Here, we highlight the importance of adopting a longitudinal approach in order to make progress into the identification of neurobiological mechanisms of social anxiety disorder (SAD). Using examples, we illustrate how longitudinal data can uniquely inform SAD etiology and timing of interventions. The brain’s inherently adaptive quality requires that we model risk correlates of disorders as dynamic in their expression. Developmental theories regarding timing of environmental events, cascading effects and (mal)adaptations of the developing brain will be crucial components of comprehensive, integrative models of SAD. We close by discussing analytical considerations in working with longitudinal, developmental data.

Original language	English
Pages (from-to)	73-82
Number of pages	10
Journal	Developmental Cognitive Neuroscience
Volume	33
Early online date	25 May 2018
DOIs	https://doi.org/10.1016/j.dcn.2018.05.005
Publication status	E-pub ahead of print - 25 May 2018

Bibliographical note

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Funding: SH was supported by a Medical Research Council studentship (Reference: 1242237) and a Scatcherd European Scholarship. CH was supported by an award from the European Research Council (‘Learning & Achievement’, Reference: 338065). KM was funded by a NIH extramural grant (Reference: R01MH107418). ASD is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London.

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When change is the only constant: The promise of longitudinal neuroimaging
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Accepted author manuscript, 490 KBLicence: CC BY-NC-ND 3.0

Cite this

@article{29c2dd312fb54eae8d33bd505c153b88,

title = "When change is the only constant: The promise of longitudinal neuroimaging in understanding social anxiety disorder",

abstract = "Longitudinal studies offer a unique window into developmental change. Yet, most of what we know about the pathophysiology of psychiatric disorders is based on cross-sectional work. Here, we highlight the importance of adopting a longitudinal approach in order to make progress into the identification of neurobiological mechanisms of social anxiety disorder (SAD). Using examples, we illustrate how longitudinal data can uniquely inform SAD etiology and timing of interventions. The brain{\textquoteright}s inherently adaptive quality requires that we model risk correlates of disorders as dynamic in their expression. Developmental theories regarding timing of environmental events, cascading effects and (mal)adaptations of the developing brain will be crucial components of comprehensive, integrative models of SAD. We close by discussing analytical considerations in working with longitudinal, developmental data.",

author = "Haller, {Simone P.W.} and Mills, {Kathryn L.} and Charlotte Hartwright and David, {Anthony S.} and {Cohen Kadosh}, Kathrin",

note = "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Funding: SH was supported by a Medical Research Council studentship (Reference: 1242237) and a Scatcherd European Scholarship. CH was supported by an award from the European Research Council ({\textquoteleft}Learning & Achievement{\textquoteright}, Reference: 338065). KM was funded by a NIH extramural grant (Reference: R01MH107418). ASD is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King{\textquoteright}s College London.",

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doi = "10.1016/j.dcn.2018.05.005",

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AU - Cohen Kadosh, Kathrin

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When change is the only constant: The promise of longitudinal neuroimaging in understanding social anxiety disorder

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