Stability of Anthracycline Cytotoxic Agents in Solution and Infusion Fluids

Abstract

Information on the stability of doxorubicin and
daunorubicin is available in the literature but data are limited and contradictory. In addition few data have been published for epirubicin. The aim of this study was to more
clearly, define the stability of these drugs in order to clarify the literature data. Reversed-phase, stability indicating
HPLC assays were developed and used to investigate the effect of pH on the rate and mechanism of
degradation by construction of a pH profile for each drug.
Degradation kinetics were studied in fluorescent light and long term stability investigated in infusion fluids...

Date of Award	Oct 1988
Original language	English
Awarding Institution	Aston University