A randomised controlled trial investigating the effect of lutein and antioxidant dietary supplementation on visual function in healthy eyes

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Abstract

Background & aims It has been suggested that retinal lutein may improve visual acuity for images that are illuminated by white light. Our aim was to determine the effect of a lutein and antioxidant dietary supplement on visual function. Methods A prospective, 9- and 18-month, double-masked randomised controlled trial. For the 9-month trial, 46 healthy participants were randomised (using a random number generator) to placebo (n=25) or active (n=21) groups. Twenty-nine of these subjects went on to complete 18 months of supplementation, 15 from the placebo group, and 14 from the active group. The active group supplemented daily with 6mg lutein combined with vitamins and minerals. Outcome measures were distance and near visual acuity, contrast sensitivity, and photostress recovery time. The study had 80% power at the 5% significance level for each outcome measure. Data were collected at baseline, 9, and 18 months. Results There were no statistically significant differences between groups for any of the outcome measures over 9 or 18 months. Conclusion There was no evidence of effect of 9 or 18 months of daily supplementation with a lutein-based nutritional supplement on visual function in this group of people with healthy eyes. ISRCTN78467674.

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  • Clinical_Nutrition_2nd_submission.pdf

    Rights statement: NOTICE: this is the author’s version of a work that was accepted for publication in Clinical Nutrition. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bartlett, Hannah E. and Eperjesi, Frank (2008). A randomised controlled trial investigating the effect of lutein and antioxidant dietary supplementation on visual function in healthy eyes. Clinical Nutrition, 27 (2), pp. 218-227. DOI 10.1016/j.clnu.2008.01.003

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Original languageEnglish
Pages (from-to)218-227
Number of pages10
JournalClinical Nutrition
Volume27
Issue2
DOIs
StatePublished - Apr 2008

Bibliographic note

NOTICE: this is the author’s version of a work that was accepted for publication in Clinical Nutrition. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bartlett, Hannah E. and Eperjesi, Frank (2008). A randomised controlled trial investigating the effect of lutein and antioxidant dietary supplementation on visual function in healthy eyes. Clinical Nutrition, 27 (2), pp. 218-227. DOI 10.1016/j.clnu.2008.01.003

    Keywords

  • lutein, visual function, randomised controlled, trial, antioxidants

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