Magnetoencephalography in epilepsy

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Magnetoencephalographic (MEG) signals, like electroencephalographic (EEG) measures, are the direct extracranial manifestations of neuronal activation. The two techniques can detect time-varying changes in electromagnetic activity with a sub-millisecond time resolution. Extra-cranial electromagnetic measures are the cornerstone of the non-invasive diagnostic armamentarium in patients with epilepsy. Their extremely high temporal resolution – comparable to intracranial recordings – is the basis for a precise definition of onset and propagation of ictal and interictal abnormalities. Given the cost of the infrastructure and equipment, MEG has yet to develop into a routinely applicable diagnostic tool in clinical settings. However, in recent years, an increasing number of patients with epilepsy have been investigated – usually in the context of presurgical evaluation of refractory epilepsies – and initial encouraging results have been reported. We will briefly review the principles and the technology behind MEG and its contribution in the diagnostic work-up of patients with epilepsy.


Publication dateApr 2012
Publication titleIntroduction to epilepsy
EditorsGonzalo Alarcón, Antonio Valentín
Place of PublicationCambridge (UK)
PublisherCambridge University Press
Number of pages3
ISBN (Electronic)978-1-13933468-6, 978-1-13910399-2
ISBN (Print)978-0-521-69158-1
Original languageEnglish

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