Rhein Parri

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Rhein Parri

Dr

 https://orcid.org/0000-0002-1412-2688

    • United Kingdom

    Personal profile

    Research Interests

    In recent years it has become clear that in addition to their traditional roles as “housekeepers” of the brain’s environment, astrocytes can also signal to neurones using many of the mechanisms previously thought exclusive to neuronal transmission. The release of such transmitters as glutamate and ATP can elicit and affect neuronal excitability and modulate synaptic transmission.

    The focus of my research group is on the mechanisms of astrocyte-neuron signalling in the thalamus, and how such signalling is involved in thalamic function. The techniques used are combined electrophysiological recording and Calcium imaging.

    Teaching Activity

    PH1401 (Module coordinator): Neuronal excitability, cardiovascular physiology, endocrinology, brain anatomy, respiration and blood pressure practical classes.
    PH2509: Anaemia, haemostasis, inotropy, vasodilators.

    Pharmacy Programme First year Tutor

    Member of the Neurophysiology  & Clinical Neuroimaging Research Group

    Employment

    • 2021 - Professor in Pharmacology, Aston University
    • 2019 - Reader in Pharmacology , Aston University
    • 2009- Senior Lecturer in Pharmacology, Aston University.
    • 2004- Lecturer in Pharmacology, Aston University.
    • 1995-2004 School of Biosciences, Cardiff University.
    • 1992-1995 Department of Pharmacology, University of California at San Francisco.
    • 1988-1992 Department of Neurophysiology, Southampton University.

    Contact Details

    Email: [email protected]
    Telephone: +44 (0) 121 204 4049
    Fax: +44 (0) 121 359 0733

    Education/Academic qualification

    PhD, Studies on Chloride in the somatic muscle bag cells of the parasitic nematode Ascaris Suum, University of Southampton

    1 Oct 1988 → 1 Oct 1991

    Award Date: 2 Dec 1991

    BSc, Physiology with Pharmacology, University of Southampton

    1 Oct 1985 → 31 Jul 1988

    Award Date: 14 Jul 1988

    Keywords

    • QP Physiology
    • glial cells
    • astrocytes
    • electrophysiology
    • calcium imaging

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    • Altered metabolic function induced by Aβ‐oligomers and PSEN1 mutations in iPSC ‐derived astrocytes

      Elsworthy, R. J., Finelli, M. J., Aqattan, S., Dunleavy, C., King, M., Ludlam, A., Tarczyluk, M. A., Allen, S. L., Prosser, S., Chen, R., Jarquin, S. M., Kim, D. H., Brown, J., Aldred, S., Parri, H. R. & Hill, E. J., Jan 2025, In: Journal of Neurochemistry. 169, 1, 20 p., e16267.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      File

    • Inferring structure of cortical neuronal networks from activity data: A statistical physics approach

      Po, H. F., Houben, A. M., Haeb, A.-C., Jenkins, D. R., Hill, E. J., Parri, H. R., Soriano, J. & Saad, D., Jan 2025, In: PNAS Nexus. 4, 1, 13 p., pgae565.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      File

    • Non-Invasive Near-Infrared Optogenetics: Aspirational Dream or Approaching Feasibility

      Galiakhmetova, D., Dremin, V., Koviarov, A., Stoliarov, D., Ngum, N., Parri, R., Gorodetsky, A., Maimaris, M., Shcherbakova, D. M., Baloban, M., Verkhusha, V. V., Sokolovsky, S. & Rafailov, E., 20 Jun 2024, Neurophotonics II. Cizmar, T. & Fellin, T. (eds.). 4 p. 1300703. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 13007).

      Research output: Chapter in Book/Published conference output › Conference publication

    • Engineering bacteriophytochrome-coupled photoactivated adenylyl cyclases for enhanced optogenetic cAMP modulation

      Xu, Q., Vogt, A., Frechen, F., Yi, C., Küçükerden, M., Ngum, N., Sitjà Roqueta, L., Greiner, A., Parri, R., Masana, M., Wenger, N., Wachten, D. & Möglich, A., 31 Aug 2023, (E-pub ahead of print) In: Journal of molecular biology. 19 p., 168257.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      File

    • First Organoid Intelligence (OI) workshop to form an OI community

      Morales Pantoja, I. E., Smirnova, L., Muotri, A. R., Wahlin, K. J., Kahn, J., Boyd, J. L., Gracias, D. H., Harris, T. D., Cohen-Karni, T., Caffo, B. S., Szalay, A. S., Han, F., Zack, D. J., Etienne-Cummings, R., Akwaboah, A., Romero, J. C., Alam El Din, D.-M., Plotkin, J. D., Paulhamus, B. L. & Johnson, E. C. & 22 others, Gilbert, F., Curley, J. L., Cappiello, B., Schwamborn, J. C., Hill, E. J., Roach, P., Tornero, D., Krall, C., Parri, R., Sillé, F., Levchenko, A., Jabbour, R. E., Kagan, B. J., Berlinicke, C. A., Huang, Q., Maertens, A., Herrmann, K., Tsaioun, K., Dastgheyb, R., Habela, C. W., Vogelstein, J. T. & Hartung, T., 28 Feb 2023, In: Frontiers in Artificial Intelligence. 6, 15 p., 1116870.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      File
    View all 56 research outputs
    • 6 Publication peer-review
    • 2 Participation in conference
    • 1 Examination
    • 1 Invited talk
    View all 10 activities