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Personal profile

Research Interests

In recent years it has become clear that in addition to their traditional roles as “housekeepers” of the brain’s environment, astrocytes can also signal to neurones using many of the mechanisms previously thought exclusive to neuronal transmission. The release of such transmitters as glutamate and ATP can elicit and affect neuronal excitability and modulate synaptic transmission.

The focus of my research group is on the mechanisms of astrocyte-neuron signalling in the thalamus, and how such signalling is involved in thalamic function. The techniques used are combined electrophysiological recording and Calcium imaging.

Teaching Activity

PH1401 (Module coordinator): Neuronal excitability, cardiovascular physiology, endocrinology, brain anatomy, respiration and blood pressure practical classes.
PH2509: Anaemia, haemostasis, inotropy, vasodilators.

Pharmacy Programme First year Tutor

Member of the Neurophysiology  & Clinical Neuroimaging Research Group

Employment

  • 2009- Senior Lecturer in Pharmacology, Aston University.
  • 2004- Lecturer in Pharmacology, Aston University.
  • 1995-2004 School of Biosciences, Cardiff University.
  • 1992-1995 Department of Pharmacology, University of California at San Francisco.
  • 1988-1992 Department of Neurophysiology, Southampton University.

Contact Details

Email: parrihr@aston.ac.uk
Telephone: +44 (0) 121 204 4049
Fax: +44 (0) 121 359 0733

Education/Academic qualification

PhD, University of Southampton

1 Oct 19881 Oct 1991

BSc, University of Southampton

1 Oct 198531 Jul 1988

Keywords

  • QP Physiology
  • glial cells
  • astrocytes
  • electrophysiology
  • calcium imaging

Fingerprint Dive into the research topics where Rhein Parri is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Astrocytes Medicine & Life Sciences
Neurons Medicine & Life Sciences
Thalamus Medicine & Life Sciences
Neuroglia Medicine & Life Sciences
Glutamic Acid Medicine & Life Sciences
astrocytes Agriculture & Biology
Brain Medicine & Life Sciences
Calcium Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1993 2018

A closer look at neuron interaction with track-etched microporous membranes

George, J. H., Nagel, D., Waller, S., Hill, E., Parri, H. R., Coleman, M. D., Cui, Z. & Ye, H., 19 Oct 2018, In : Scientific Reports. 8, 1, 15552.

Research output: Contribution to journalArticle

Open Access
File
Neurites
Neurons
Membranes
Growth
Electron Scanning Microscopy

In vitro Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells

Grainger, A. I., King, M. C., Nagel, D. A., Parri, H. R., Coleman, M. D. & Hill, E. J., 31 Aug 2018, In : Frontiers in Neuroscience. 12, AUG, 590.

Research output: Contribution to journalReview article

Open Access
File
Induced Pluripotent Stem Cells
Seizures
Rodentia
Electrodes
Central Nervous System

Printing brain in vitro at 3D scaffolds: materials and patterns

Sokolovski, S. G., Crowe, J. A., Nagel, D., Hill, E. J., El-tamer, A., Koroleva, A. V., Parri, R., Chichkov, B. N. & Rafailov, E. U., 16 Aug 2018, 2018 International Conference Laser Optics (ICLO). IEEE, p. 504-504

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Induced Pluripotent Stem Cells
Printing
Neuroglia
Technology
Brain

Astrocyte mediated neuronal synchronization properties revealed by false gliotransmitter release

Pirttimaki, T. M., Sims, R. E., Saunders, G., Antonio, S. A., Codadu, N. K. & Parri, H. R., 11 Oct 2017, In : Journal of Neuroscience. 37, 41, p. 9859-9870 12 p.

Research output: Contribution to journalArticle

Open Access
File
Astrocytes
Neurons
Glutamic Acid
D-Aspartic Acid
N-Methylaspartate

Astrocytes modulate thalamic sensory processing via mGlu2 receptor activation

Copeland, C. S., Wall, T. M., Sims, R. E., Neale, S. A., Nisenbaum, E., Parri, H. R. & Salt, T. E., 15 Jul 2017, In : Neuropharmacology. 121, p. 100-110 11 p.

Research output: Contribution to journalArticle

Open Access
File
eglumetad
N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3-ylmethylamine
Thalamus
Astrocytes
Neurons

Thesis

Astrocyte-neuron signalling by synaptic stimulation in the ventrobasal thalamus

Author: Pirttimäki, T., Feb 2009

Supervisor: Parri, H. R. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Aβ(1-42) induced metabolic effects in a stem cell derived neuron and astrocyte network.

Author: Tarczyluk, M., 30 Jul 2013

Supervisor: Parri, H. R. (Supervisor) & Hill, E. J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Investigating novel interaction partners of amyloid precursor protein: the mechanistic target of rapamycin and pikyve complex

Author: Guscott, B., 5 Dec 2016

Supervisor: Wassmer, T. (Supervisor), Balklava, Z. (Supervisor) & Parri, H. R. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

The role of amyloid precursor protein in neuronal and non-neuronal cell lines

Author: Tse, E., 3 Dec 2015

Supervisor: Hill, E. J. (Supervisor) & Parri, H. R. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Activities 2010 2012

  • 6 Publication peer-review
  • 2 Participation in conference
  • 1 Examination
  • 1 Invited talk

Frontiers in Cellular Neuroscience (Journal)

Rhein Parri (Peer reviewer)
May 2012

Activity: Publication peer-review and editorial work typesPublication peer-review

PLoS ONE (Journal)

Rhein Parri (Peer reviewer)
May 2012

Activity: Publication peer-review and editorial work typesPublication peer-review

Chinese Journal of Physiology (Journal)

Rhein Parri (Peer reviewer)
Apr 2012

Activity: Publication peer-review and editorial work typesPublication peer-review

Epilepsy Research UK International Expert Workshop

Rhein Parri (Participant)
15 Mar 2012

Activity: Participating in or organising an event typesParticipation in conference

Frontiers in Neuropharmacology (Journal)

Rhein Parri (Peer reviewer)
Mar 2012

Activity: Publication peer-review and editorial work typesPublication peer-review