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Personal profile

Research Interests

In recent years it has become clear that in addition to their traditional roles as “housekeepers” of the brain’s environment, astrocytes can also signal to neurones using many of the mechanisms previously thought exclusive to neuronal transmission. The release of such transmitters as glutamate and ATP can elicit and affect neuronal excitability and modulate synaptic transmission.

The focus of my research group is on the mechanisms of astrocyte-neuron signalling in the thalamus, and how such signalling is involved in thalamic function. The techniques used are combined electrophysiological recording and Calcium imaging.

Teaching Activity

PH1401 (Module coordinator): Neuronal excitability, cardiovascular physiology, endocrinology, brain anatomy, respiration and blood pressure practical classes.
PH2509: Anaemia, haemostasis, inotropy, vasodilators.

Pharmacy Programme First year Tutor

Member of the Neurophysiology  & Clinical Neuroimaging Research Group

Employment

  • 2009- Senior Lecturer in Pharmacology, Aston University.
  • 2004- Lecturer in Pharmacology, Aston University.
  • 1995-2004 School of Biosciences, Cardiff University.
  • 1992-1995 Department of Pharmacology, University of California at San Francisco.
  • 1988-1992 Department of Neurophysiology, Southampton University.

Contact Details

Email: parrihr@aston.ac.uk
Telephone: +44 (0) 121 204 4049
Fax: +44 (0) 121 359 0733

Education/Academic qualification

PhD, University of Southampton

1 Oct 19881 Oct 1991

Award Date: 2 Dec 1991

BSc, University of Southampton

1 Oct 198531 Jul 1988

Award Date: 14 Jul 1988

Keywords

  • QP Physiology
  • glial cells
  • astrocytes
  • electrophysiology
  • calcium imaging

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Research Output

Development of two-photon polymerised scaffolds for optical interrogation and neurite guidance of human iPSC-derived cortical neuronal networks

Crowe, J. A., El-Tamer, A., Nagel, D., Koroleva, A. V., Madrid-Wolff, J., Olarte, O. E., Sokolovsky, S., Estevez-Priego, E., Ludl, A-A., Soriano, J., Loza-Alvarez, P., Chichkov, B. N., Hill, E. J., Parri, H. R. & Rafailov, E. U., 19 May 2020, In : Lab on a Chip. 20, 10, p. 1792-1806 15 p.

Research output: Contribution to journalArticle

Open Access
File
  • Neuromodulators and long-term synaptic plasticity in learning and memory: A steered-glutamatergic perspective

    Bazzari, A. H. & Parri, H. R., 31 Oct 2019, In : Brain Sciences. 9, 11, 300.

    Research output: Contribution to journalReview article

    Open Access
    File
  • A closer look at neuron interaction with track-etched microporous membranes

    George, J. H., Nagel, D., Waller, S., Hill, E., Parri, H. R., Coleman, M. D., Cui, Z. & Ye, H., 19 Oct 2018, In : Scientific Reports. 8, 1, 15552.

    Research output: Contribution to journalArticle

    Open Access
    File
  • In vitro Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells

    Grainger, A. I., King, M. C., Nagel, D. A., Parri, H. R., Coleman, M. D. & Hill, E. J., 31 Aug 2018, In : Frontiers in Neuroscience. 12, AUG, 590.

    Research output: Contribution to journalReview article

    Open Access
    File
  • Printing brain in vitro at 3D scaffolds: materials and patterns

    Sokolovski, S. G., Crowe, J. A., Nagel, D., Hill, E. J., El-tamer, A., Koroleva, A. V., Parri, R., Chichkov, B. N. & Rafailov, E. U., 16 Aug 2018, 2018 International Conference Laser Optics (ICLO). IEEE, p. 504-504

    Research output: Chapter in Book/Report/Conference proceedingConference publication

  • Activities

    • 6 Publication peer-review
    • 2 Participation in conference
    • 1 Examination
    • 1 Invited talk

    Frontiers in Cellular Neuroscience (Journal)

    Rhein Parri (Peer reviewer)

    May 2012

    Activity: Publication peer-review and editorial work typesPublication peer-review

    PLoS ONE (Journal)

    Rhein Parri (Peer reviewer)

    May 2012

    Activity: Publication peer-review and editorial work typesPublication peer-review

    Chinese Journal of Physiology (Journal)

    Rhein Parri (Peer reviewer)

    Apr 2012

    Activity: Publication peer-review and editorial work typesPublication peer-review

    Epilepsy Research UK International Expert Workshop

    Rhein Parri (Participant)

    15 Mar 2012

    Activity: Participating in or organising an event typesParticipation in conference

    Frontiers in Neuropharmacology (Journal)

    Rhein Parri (Peer reviewer)

    Mar 2012

    Activity: Publication peer-review and editorial work typesPublication peer-review