β-amyloid (Aβ) deposition in cognitively normal brain, dementia with Lewy bodies, and Alzheimer's disease: a study using principal components analysis

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

The densities of diffuse, primitive, and classic ß-amyloid (Aß) deposits were studied in the temporal lobe in cognitively normal brain, dementia with Lewy bodies (DLB), familial Alzheimer’s disease (FAD), and sporadic AD (SAD). Principal components analysis (PCA) was used to determine whether there were distinct differences between groups or whether Aß pathology was more continuously distributed from group to group. Three principal components (PC) were extracted from the data accounting for 56% of the total variance. Plots of cases in relation to the PC did not result in distinct groups but suggested overlap in Aß deposition between the groups. In addition, there were linear correlations between the densities of Aß deposits and the distribution of the cases along the PC in specific brain regions suggesting continuous variation from group to group. PC1 was associated with the degree of maturation of Aß deposits, PC2 with differences between FAD and SAD, and PC3 with the degree of spread of Aß pathology into the hippocampus. Apolipoprotein E (APOE) genotype was not associated with variation in Aß deposition between cases. PCA may be a useful method of studying the pathological interface between closely related neurodegenerative disorders.
LanguageEnglish
Pages130-139
Number of pages10
JournalFolia Neuropathologica
Volume50
Issue number2
Publication statusPublished - Jul 2012

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Lewy Body Disease
Principal Component Analysis
Amyloid
Dementia
Alzheimer Disease
Pathology
Amyloid Plaques
Brain
Apolipoproteins E
Temporal Lobe
Neurodegenerative Diseases
Hippocampus
Genotype

Bibliographical note

© 2015 Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Keywords

  • cognitively normal brain
  • dementia with Lewy bodies
  • Alzheimer disease
  • β-amyloid deposits
  • principal component analysis

Cite this

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β-amyloid (Aβ) deposition in cognitively normal brain, dementia with Lewy bodies, and Alzheimer's disease : a study using principal components analysis. / Armstrong, Richard A.

In: Folia Neuropathologica, Vol. 50, No. 2, 07.2012, p. 130-139.

Research output: Contribution to journalArticle

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