In this paper, we develop a new mixed entropy local-global reproducing kernel for vertex attributed graphs based on depth-based representations that naturally reflect both local and global entropy based graph characteristics. Specifically, for a pair of graphs, we commence by computing the nest depth-based representations rooted at the centroid vertices. The resulting mixed local-global reproducing kernel for a pair of graphs is computed by measuring a basic H1-reproducing kernel between their nest representations associated with different entropy measures. We show that the proposed kernel not only reflect both the local and global graph characteristics through the nest depth-based representations, but also reflect rich edge connection information and vertex label information through different kinds of entropy measures. Moreover, since both the required basic H1-reproducing kernel and the nest depth-based representation can be computed in a polynomial time, the new proposed kernel processes efficient computational complexity. Experiments on standard graph datasets demonstrate the effectiveness and efficiency of the proposed kernel.