A model for the modular evolution of rna addressing open questions on the origin of life

Carlos Briones; Michael Stich; Susanna C. Manrubia

doi:10.1007/s11084-010-9213-2

Abstract

A main unsolved problem in the RNA world scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers generated by random polymerization of ribonucleotides (Joyce and Orgel 2006). Current estimates establish a minimum size about 165 nt long for such a ribozyme (Johnston et al. 2001), a length three to four times that of the longest RNA oligomers obtained by random polymerization on clay mineral surfaces (Huang and Ferris 2003, 2006). To overcome this gap, we have developed a stepwise model of ligation-based, modular evolution of RNA (Briones et al. 2009) whose main conceptual steps are summarized in Figure 1. This scenario has two main advantages with respect to previous hypotheses put forward for the origin of the RNA world: i) short RNA....

Original language	English
Pages (from-to)	429-432
Number of pages	4
Journal	Origins of Life and Evolution of Biospheres
Volume	40
Issue number	4-5
DOIs	https://doi.org/10.1007/s11084-010-9213-2
Publication status	Published - 2010
Event	Open Questions on the Origins of Life 2009 - San Sebastian-Donostia, Spain Duration: 20 May 2009 → 23 May 2009

Bibliographical note

Workshop OQOL’09: Open Questions on the Origins of Life 2009

Keywords

functional complexity
modular evolution
Rna ligation
Rna replicase
Rna world
hairpin
ribozyme

Access to Document

10.1007/s11084-010-9213-2

Cite this

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title = "A model for the modular evolution of rna addressing open questions on the origin of life",

abstract = "A main unsolved problem in the RNA world scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers generated by random polymerization of ribonucleotides (Joyce and Orgel 2006). Current estimates establish a minimum size about 165 nt long for such a ribozyme (Johnston et al. 2001), a length three to four times that of the longest RNA oligomers obtained by random polymerization on clay mineral surfaces (Huang and Ferris 2003, 2006). To overcome this gap, we have developed a stepwise model of ligation-based, modular evolution of RNA (Briones et al. 2009) whose main conceptual steps are summarized in Figure 1. This scenario has two main advantages with respect to previous hypotheses put forward for the origin of the RNA world: i) short RNA....",

keywords = "functional complexity, modular evolution, Rna ligation, Rna replicase, Rna world, hairpin, ribozyme",

author = "Carlos Briones and Michael Stich and Manrubia, {Susanna C.}",

note = "Workshop OQOL{\textquoteright}09: Open Questions on the Origins of Life 2009; Open Questions on the Origins of Life 2009, Workshop OQOL{\textquoteright}09 ; Conference date: 20-05-2009 Through 23-05-2009",

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AU - Briones, Carlos

AU - Stich, Michael

AU - Manrubia, Susanna C.

N1 - Workshop OQOL’09: Open Questions on the Origins of Life 2009

PY - 2010

Y1 - 2010

N2 - A main unsolved problem in the RNA world scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers generated by random polymerization of ribonucleotides (Joyce and Orgel 2006). Current estimates establish a minimum size about 165 nt long for such a ribozyme (Johnston et al. 2001), a length three to four times that of the longest RNA oligomers obtained by random polymerization on clay mineral surfaces (Huang and Ferris 2003, 2006). To overcome this gap, we have developed a stepwise model of ligation-based, modular evolution of RNA (Briones et al. 2009) whose main conceptual steps are summarized in Figure 1. This scenario has two main advantages with respect to previous hypotheses put forward for the origin of the RNA world: i) short RNA....

AB - A main unsolved problem in the RNA world scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers generated by random polymerization of ribonucleotides (Joyce and Orgel 2006). Current estimates establish a minimum size about 165 nt long for such a ribozyme (Johnston et al. 2001), a length three to four times that of the longest RNA oligomers obtained by random polymerization on clay mineral surfaces (Huang and Ferris 2003, 2006). To overcome this gap, we have developed a stepwise model of ligation-based, modular evolution of RNA (Briones et al. 2009) whose main conceptual steps are summarized in Figure 1. This scenario has two main advantages with respect to previous hypotheses put forward for the origin of the RNA world: i) short RNA....

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